Piperazinealkanoic acid and a pharmaceutical composition compris

Details Piperazinealkanoic acid and a pharmaceutical composition compris Piperazinealkanoic acid and a pharmaceutical composition compris

1991-03-01

1994-09-06

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514217, 540551, 540587, 540579, A61K 3155, C07D40304, C07D41304, C07D41704

Patent

active

053448286

ABSTRACT:
Novel polycyclic compounds represented by the following formula: A--(CH.sub.2).sub.n --COOR.sup.1, wherein R.sup.1 represents a hydrogen atom or a lower alkyl group; n represents an integer of from 0 to 5; and A is a group represented by the following formula: ##STR1## wherein X represents a hydrogen atom or a halogen atom; and Y represents a methylene group, an oxygen atom, or a sulfur atom, or A is a group represented by the following formula: ##STR2## and pharmacologically acceptable salts thereof are disclosed. Also disclosed are a method for preparing the same, a pharmaceutical composition comprising the same, an antiallergic agent and an agent for bronchial asthma comprising the same, and a method for treatment of an allergic disease or bronchial asthma comprising the step of administering the same.

REFERENCES:
patent: 3389139 (1968-06-01), Schmutz et al.
patent: 3546226 (1970-12-01), Schmutz et al.
patent: 3845074 (1974-10-01), Malen et al.
patent: 3928356 (1975-12-01), Umio et al.
Kaspersen et al. Recl: Journal of the Royal Netherlands Chem. Soc., 102(10), pp. 457-460, (1983).
Chemical Abstract, vol. 100, No. 34501n, (1983), Kaspersen.
Chemical Abstract, 11th Collective Index, 1982-1986 Substance Index.
Stedman's Medical Dictionary, 24th Edition, (Publ. by Williams & Wilkins), p. 133, (1982).
Martin et al., "The Pharmacological Properties of a New, Orally Active Antianaphylactic Compound: Ketotifen, a Benzocycloheptathiophene", Arzneim.-Forsch./Drug Res., 28, (1978); (Experiment 2.2.6.), pp. 770-782.
Folia Pharmacol., Japan, 80, (1982), pp. 251-260, Ohmori et al.
"Disodium Cromoglycate (FPL 670) (`Intal`): a Specific Inhibitor of Reaginic Antibody-Antigen Mechanisms", Nature, 216, (1967), pp. 1328-1329, Cox.
Howell et al., "A Double-Blind Trial of Disodium Cromoglycate in the Treatment of Allergic Bronchial Asthma", The Lancet, 9, (1967), pp. 539-542.
"Ketotifen", Drugs of the Future, 11, (1977), pp. 108-111, Castaner et al.
Partial European Search Report and Annex to the European Search Report on Patent Appln. EP 91-10-3059, (1991).
"The Merck Index", Encyclopedia of Chemicals, Drugs, and Biologicals, 11th Ed., (1989), pp. 91, 377, 971, and 1138, Rahway, N.J.

Affiliated with

Also associated with

Rating

Piperazinealkanoic acid and a pharmaceutical composition compris does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Piperazinealkanoic acid and a pharmaceutical composition compris, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Piperazinealkanoic acid and a pharmaceutical composition compris will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1329606