Use of OB-101 to treat inflammation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514912, 424427, 424429, A61K 31535

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active

053448294

ABSTRACT:
A novel compound for the treatment and prevention of ocular and other types of inflammation is disclosed. The compound, OB-101, is effective at both the early and late phases of inflammation. The compound is useful for the treatment of inflammation in both the anterior and posterior portions of the eye, as well as in other parts of the body.

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Polansky, J. R., et al., "Anti-inflammatory agents: steroids as anti-inflammatory agents" Sears, ed., Handbook of Experimental Pharmacology Springer-Verlag, (1985) 69:459-538.
Miyano, K., et al., "Pharmacological prevention of ocular inflammation induced by lens proteins" Ophthalmic Res. (1984) 16:256-263.
Chiou, L. Y., et al., "Ocular anti-inflammatory action of a lipooxygenase inhibitor in the rabbit" J. Ocular Pharmacology (1985) 1(4):383-390.
Bhattacherjee, P., et al., "Effect of lipooxygenase products on leukocyte accumulation in the rabbit eye" Leukotrienes and Other Lipooxygenase Products, Samuelsson, B., et al., eds., Raven Press, New York, (1988) pp. 325-330.
Chang, M. S., et al., "Prevention of lens protein-induced ocular inflammation with cycloxygenase and cycloxygenase and lipooxygenase inhibitors" J. Ocular Pharmacology (1989) 5(4): 353-360.
Walsh, J. B., et al., eds., Physicians' Desk Reference for Ophthalmology, Edward R. Barnhart, Publisher, 16th edition, (1988) p. 9.

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