Physiologically active substances PF1092A, PF1092B and PF1092C,

Details Physiologically active substances PF1092A, PF1092B and PF1092C, Physiologically active substances PF1092A, PF1092B and PF1092C,

1996-01-11

1998-01-27

Trinh, Ba K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549299, A61K 3134, C07D30777

Patent

active

057123063

ABSTRACT:
This invention provides novel physiologically active substances PF1092A, PF1092B and PF1092C, which can inhibit binding of progesterone to progesterone receptor.
These substances were obtained by culturing a fungal microorganism belonging to the genus Penicillium using a medium containing ordinary nutrients for microorganisms and isolating the physiologically active substances PF1092A, PF1092B and PF1092C from the resulting culture mixture by means of solvent extraction, silica gel column chromatography, and the like. Molecular formulae of the novel physiologically active substances PF1092A, PF1092B and PF1092C are C.sub.17 H.sub.20 O.sub.5, C.sub.17 H.sub.20 O.sub.5 and C.sub.15 H.sub.18 O.sub.4, respectively.

REFERENCES:
K. Yamakawa et al., "Studies on the Terpenoids and Related Aclicyclic Compounds . . . and (+-)-Furanoligularanone", Chemical and Pharmaceutical Bulletin, 28:11:3265-3274, (1980).
I.S. Levina et al., "Relationship Between Structure and Mode of Action of 16.alpha., 17.alpha.-cycloalkanoprogesterones (pregna-D'-pentaranes)", Chemical Abstracts, 98:21:118, col. 2, (1983).

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