Physiologically active substance-prolonged releasing-type pharma

Details Physiologically active substance-prolonged releasing-type pharma Physiologically active substance-prolonged releasing-type pharma

1994-09-20

1997-06-10

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424457, 424468, 424426, 5147723, 514777, 514781, 514784, 514785, 514808, 514929, A61F 200, A61K 920

Patent

active

056373090

ABSTRACT:
A prolonged releasing pharmaceutical preparation is provided carrying a physiologically active substance, particularly, calcitonin gene-related peptide (CGRP) or a maxadilan (MAX). This pharmaceutical preparation can attain the expected effects by incorporating the physiologically active substance into a combination, as carriers for the physiologically active substance, of a cellulosic polymer and at least one auxiliary component selected from the group consisting of fats and oils, waxes, fatty acids, saccharides and polyacrylate ester derivatives. The pharmaceutical preparation can conveniently be used, in living bodies, particularly as an intrathecal implantation-type preparation.

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patent: 4882167 (1989-11-01), Jang
patent: 5112614 (1992-05-01), Magruder et al.
patent: 5236908 (1993-08-01), Gruber et al.
patent: 5252318 (1993-10-01), Joshi et al.
patent: 5356629 (1994-10-01), Sander et al.
Park et al., "Biodegradable Hydrogels for Drug Delivery", pp. 211-212 (1993).
Lerner et al., "Isolation of Maxadilan, a Potent Vasodilatory Peptide from the Salivary Glands of the Sand Fly Lutzomyia longipalpis", The Journal of Biological Chemistry, vol. 266, No. 17, Jun. 15, 1991, pp. 11234-11236.
Lerner et al., J. Biol. Chem., "Maxadilan: Cloning and Functional Expression of the Gene Encoding This Potent Vasodilator Peptide", vol. 267, pp. 1062-1066 (Jan. 15, 1992).
Ohnuma et al., Peptide Chemistry 1993 "Vasodilatory Peptide `Maxadilan`", Okada (Ed.) pp. 145-148 (1993).
Shimizu et al., Nou Shinkei Geka (Neurosurgery) 22(2): 131-139 (Feb. 1994) and partial translation.

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