Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1978-08-31
1980-06-03
Morgenstern, Norman
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
2602391, A61K 3143, C07D49968
Patent
active
042062187
ABSTRACT:
Penicillin esters and their acid addition salts of the formula ##STR1## wherein X is hydrogen, methyl, methoxy, chloro, or bromo and n is an integer from 1 to 3 provided that n is 2 or 3 only when X is hydrogen or methoxy; are disclosed. Upon oral administration, these esters provide improved absorption and result in high concentrations of the antibacterially active parent penicillin in the blood, tissues and urine.
REFERENCES:
patent: Re29650 (1978-05-01), Ferres
patent: 3198804 (1965-08-01), Johnson et al.
patent: 3485819 (1969-12-01), Weisenborn et al.
patent: 3846417 (1974-11-01), Atwal et al.
patent: 3860579 (1975-01-01), Ferres et al.
patent: 3951954 (1976-04-01), Marakami et al.
patent: 4036829 (1977-07-01), Ferres et al.
patent: 4072677 (1978-02-01), Callander
Clayton et al., J. Medicinal Chem. vol. 19, pp. 1385-1391, (1976).
Merck Index, 9th Ed. (1976) Entries 624, 3539, 4536, A14.
Brown William E.
Cimarusti Christopher M.
Clarke Vera C.
Davis Stephen B.
E. R. Squibb & Sons Inc.
Levinson Lawrence S.
Lovercheck Dale
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