Phthalazines containing an aromatic ether or thioether group in

Details Phthalazines containing an aromatic ether or thioether group in Phthalazines containing an aromatic ether or thioether group in

1992-10-20

1994-10-11

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544237, C07D23732, A61K 3150

Patent

active

053547500

ABSTRACT:
Pharmacologically active compounds of the General Formula ##STR1## where X is oxygen or sulphur and the radical R represents a quinuclidyl radical, an C.sub.1 -C.sub.6 -alkyl radical, a phenyl radical, a pyridyl radical, a phenyl or pyridyl radical substituted by the radicals R.sub.1, R.sub.2, and/or R.sub.3, a C.sub.1 -C.sub.6 -alkyl radical substituted by pyridyl or alkylpyridyl or a C.sub.1 -C.sub.6 -alkyl radical substituted by phenyl, where each phenyl radical may also be substituted by the radicals R.sub.1, R.sub.2 and/or R.sub.3 and the radicals R.sub.1, R.sub.2 and R.sub.3 are the same or different and represent hydrogen, halogen, trihalogenmethyl, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, carboxy, Carb-C.sub.1 -C.sub.6 -alkoxy, amino, C.sub.1 -C.sub.6 -alkylamino, C.sub.1 -C.sub.6 -dialkylamino, C.sub.1 -C.sub.6 -trialkylamino, C.sub.2 -C.sub.6 -alkanoylamino, or C.sub.2 -C.sub.6 -alkanoylamino which contains one more amino group in the alkyl portion, and their physiologically acceptable acid addition salts. The compounds provide analgesic, anti-inflammatory, anti-convulsive and anti-pyretic effects.

REFERENCES:
patent: 2484029 (1949-10-01), Hartmann
patent: 3882119 (1975-05-01), Nathansohn
patent: 4925843 (1990-05-01), Takahashi
Hayashi, Chem Abs 58, 3425 (1962).
Uoda, Chem Abs 88, 136646q (1977).

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