Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1980-05-12
1982-04-27
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
424200, 424202, 424203, 424214, 542412, 542438, 542439, 536 4, 260946, 260463, 560108, 560125, A61K 3166, A61K 3172, C07F 938, C07H 1520
Patent
active
043270883
ABSTRACT:
Compounds of the formula: ##STR1## wherein R.sub.1 is hydroxy, phosphonooxy, aminoglycosyloxy, acylaminoglycosyloxy, benzyloxycarbonyloxy, arylcarbonyloxy, trialkylammonio-acyloxy or furoyloxy; R.sub.2 and R.sub.3 each are lower alkoxy; and R.sub.4 is benzimidazolyl, furyl which is unsubstituted or substituted with lower alkyl, thienyl which is unsubstituted or substituted with lower alkyl, or phenyl which is substituted with lower alkyl, lower alkoxy, alkoxyalkoxy, alkylthio, alkylenedioxy, or acyloxy, with the proviso that when R.sub.1 is hydroxy, R.sub.4 is benzimidazolyl or phenyl which is substituted by acyloxy or alkoxyalkoxy, or pharmaceutically acceptable salts thereof useful as antiviral agents.
REFERENCES:
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patent: 4122191 (1978-10-01), Parker
patent: 4154756 (1979-05-01), Shepherd
Venturella et al., Chem. Abst. 1961, vol. 55, col. 9412c.
Mahanty et al., Chem. Abst. 1965, vol. 63, col. 4201c.
Haensel et al., Chem. Abst. 1963, vol. 59, col. 9018a.
Stedman's Medical Dictionary, 23rd Ed., Williams & Wilkins, Baltimore, 1976, p. 1560.
Fraser et al., Chem. Abst. 1974, vol. 81, No. 114603h.
Kohler et al., Organic Syntheses, vol. II, Wiley, NY, 1922, pp. 1-3.
Ishitsuka Hideo
Shinma Nobuo
Suhara Yasuji
Umeda Isao
Harkaway Natalia
Hoffmann-La Roche Inc.
Jiles Henry R.
Johnston George W.
Leon Bernard S.
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