Phosphonate inhibitors of HCV

Details Phosphonate inhibitors of HCV Phosphonate inhibitors of HCV

2007-07-06

2010-11-30

Lewis, Patrick T (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S045000, C514S046000, C514S047000, C514S048000, C514S049000, C514S050000, C514S051000, C514S052000

Reexamination Certificate

active

07842672

ABSTRACT:
A compound of Formula I, Formula II, Formula III, or Formula IV:or a pharmaceutically acceptable salt, solvate, and/or ester thereof, therapeutic compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

REFERENCES:
patent: 4968788 (1990-11-01), Farquhar
patent: 5663159 (1997-09-01), Starrett, Jr. et al.
patent: 5688778 (1997-11-01), Kim et al.
patent: 5798340 (1998-08-01), Bischofberger et al.
patent: 6018049 (2000-01-01), Hajima et al.
patent: 6127121 (2000-10-01), Meyer, Jr. et al.
patent: 6143877 (2000-11-01), Meyer et al.
patent: 2002/0103378 (2002-08-01), Ellis
patent: 2004/0023921 (2004-02-01), Hong et al.
patent: 2004/0100960 (2004-05-01), Mehta
patent: 2004/0147464 (2004-07-01), Roberts et al.
patent: 2005/0215511 (2005-09-01), Roberts et al.
patent: 2005/0215513 (2005-09-01), Boojamra et al.
patent: 398231 (1990-11-01), None
patent: 0 632 048 (2001-03-01), None
patent: WO 95/07920 (1995-03-01), None
patent: WO 96/15111 (1996-05-01), None
patent: WO 01/38584 (2001-05-01), None
patent: WO-01/60379 (2001-08-01), None
patent: WO-02/057287 (2002-07-01), None
patent: WO-03/026589 (2003-04-01), None
patent: WO 03/061385 (2003-07-01), None
patent: WO 03/062257 (2003-07-01), None
patent: WO-03/072757 (2003-09-01), None
patent: WO 03/073989 (2003-09-01), None
patent: WO-2004/028481 (2004-04-01), None
patent: WO-2004/096233 (2004-11-01), None
patent: WO-2004/096235 (2004-11-01), None
patent: WO-2004/096286 (2004-11-01), None
patent: WO 2005/021568 (2005-03-01), None
patent: WO-2005/123087 (2005-12-01), None
patent: WO 2005/123087 (2005-12-01), None
patent: WO 2006/000922 (2006-01-01), None
patent: WO 2006/002231 (2006-01-01), None
patent: WO-2006/050161 (2006-05-01), None
Charubala et al. (2002) “Inhibition of HIV-1 Replication by Chemically Synthesized, Nuclease-Resistant, Nontoxic (2′-5′)-Oligoadenylate Agonists,”Helvetica Chimica Acta85:2284-2299.
Kim et al. (1991) “Regiospecific and Highly Stereoselective Electrophilic Addition to Furanoid Glycals: Synthesis of Phosphonate Nucleotide Analogues with Potent Activity Against HIV,”J Org. Chem. 56:2642-2647.
Meier et al. (1991) “O-Alkyl-5′, 5′-Dinucleoside-Phosphates as Combined Prodrugs of Antiviral and Antibiotic Compounds,”Bioorganic&Medicinal Chemistry Letters1(10)327-330.
Stuyver et al. (2003) “Ribonucleoside Analogue that Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in Culture,”Antimicrobial Agents and Chemotherapy47(1):244-254.
Zhang et al. (2001) “Novel Synthesis of [33 p]- (2-Chloroethyl)phosphonic Acid,”J Org. Chem. 66:327-329.
Alexander et al. “Preparation of 9-(2-Phosphonomethoxyethyl) Adenine Esters as Potential Prodrugs” 59:1853; Collect Czech Chem Commun., 1994.
Anan'eva et al.“(2-lodoethyl)Phosphonic Derivatives.” 53(3):480-483; J. Gen. Chem. USSR., 1983.
Anderson et al. “2-Chloro-4(R),5(R)-dimethyl-2-oxo-1,3,2-dioxaphospholane, a New Chiral Derivatizing Agent.” 49:1304-1305; J Org Chem., 1984.
Bai et al. “Structural Specificity of Mucosal-Cell Transport and Metabolism of Peptide Drugs: Implication for Oral Peptide Drug Delivery.” 9:969-979;Pharm Res., 1992.
Balsiger et al. “Synthesis of Potential Anticancer Agents. XVIII. Analogs of Carbamoyl Phosphate.” 24:434-436; J Org Chem., 1959.
Balthazor et al. “Nickel-Catalyzed Arbuzov Reaction: Mechanistic Observations.” 45:5425-5426;J Org Chem., 1980.
Benzaria et al. “Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Bis(S-acyl-2-thioethyl) Ester Derviatives . . . ” 39:4958-4965; J Med Chem., 1996.
Beusen et al. “Solid-State Nuclear Magnetic Resonance Anlysis of the Conformation of an Inhibitor Bound to Thermolysin.” 38: 2742-2747; J Med Chem., 1995.
Bhuta et al. “Analogues of Chloramphenicol: Circular Dichroism Spectra, Inhibition of Ribosomal Peptidyltransferase, and Possible . . . ” 23(12):1299-1305;J Med Chem., 1980.
Burger et al. “Monoesters and Ester-amidates of Aromatic Phosphonic Acids.” 79:3575-3579; J Am Chem Soc.,1957.
Campagne et al. “(1H-Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium Hexafluorophosphate-and . . . ” 60(16):5214-5223;J Org Chem., 1995.
Campagne et al. “Synthesis of Mixed Phosphonate Diester Analogues of Dipeptides Using BOP or PyBOP Reagents.” 34:6743-6744; Tet Lett., 1993.
Campbell et al. “The Synthesis of Phosphonate Esters, an Extension of the Mitsunobu Reaction.” 57:6331-6335; J Org Chem., 1992.
Casteel et al. “Steric and Electronics Effects in the Aryl Phosphate to Aryiphosphonate Rearrangement.” 691-693;Synthesis., 1991.
Cavalier et al. “New Highly Diastereoselective Synthesis of Phosphoramidates. A Route to Chiral Methyl p-Nitrophenyl Alkylphosphonates.” 1:73-75; Synlett., 1998.
Chen et al “Design, Synthesis, and Biochemical Evaluation of Phosphonate and Phosphonamidate Analogs of Glutathionylspermidine . . . ” 40(23):3842-3850;J Med Chem.,1997.
Clayton et al. “BRL.8988 (Talampicillin), a Well-Absorbed Oral Form of Ampicillin.” 5(6):670-671;Antimicro AG & Chemo., 1974.
Coe et al. “Synthesis of Some Mimics of Nucleoside Triphosphates.” pp. 312-314; J. Chem. Soc. Chem. Commun.., 1991.
Corey et al “Selective Cleavage of Allyl Ethers Under Mild Conditions by Transition Metal Reagants.” 38(18):3224;J Org Chem., 1973.
Davies et al. “Dinucleotide Analogues as Inhibitors of Thymidine Kinase, Thyidylate Kinase, and Ribonucleotide Reductase.” 31(7)1 305-1308;J Med Chem.,1988.
Efimov et al. “Synthesis of DNA Analogues with Novel Carboxamidomethyl Phosphonamide and Glycinamide Internucleoside Linkages.” 8:1013-1018; Bioorg Med Chem Lett., 1998.
Eliel et al., p. 322-381; Stereochem Org Comp., 1994.
Fasman et al., pp. 385-394; Practical Handbook of Biochem and Molec Biol.,1989.
Freeman et al.“3 Prodrug Design for Phosphantes and Phosphonates” 34:112-147; Progress in Medicinal Chemistry., 1997.
Galeotti et al. “A Straightforward Synthesis of -Amino Phosphonate Monoesters Using BroP or TPyCIU.” 37(23):3997-3998; Tet Lett., 1996.
Greene et al. “Protection for the Amino Acids.” 7:309-405; Protective Groups in Organic Synthesis (2nd Ed.) (John Wiley & Sons).,1991.
Griffin et al. “D-Glucopyranose 5-Deoxy-6-phosphonic Acid.” 78(10):2336-2338; J Am Chem Soc.,1956.
Hakimelahi et al. “Design, Synthesis, and Structure-Activity Relationship of Novel Dinucleotide Analogs as Agents against Herpes, . . . ” 38:4648-4659, J. Med Chem., (1995).
Jacob III, Peyton “Resolution of ( )-5-Bromonornicotine. Synthesis of (R)- and (S)- Nornicotine of High Enantiomeric Purity.” 47:4165-4167; J Org Chem., 1982.
Khandazhinskaya et al.“Carbocyclic Dinucleoside Polyphosphonates: Interactions with HIV reverse Transcriptase and Antiviral Activity.” 45:1284-1291;J Med Chem., 2002.
Kunz et al. “71. Synthesis of the Glycopeptide Partial Sequence A 80-A84 of Human Fibroblast Interferon.” 68:618-622;Helvetica Chimica Acta., 1985.
Lochmuller et al. “Chromatographic Resolution of Enantiomers Selective Review.” 113:283-302;J Chromatog., 1975.
Lohmann et al.“Replication of Subgenomic Hepatitis C Virus RNA's in a Hepatoma Cell Line.” 285:110-113; Science., 1999.
Lu et al. “Palladium-Catalyzed Reaction of Aryl Polyfluoroalkanesulfonates with 0,0-Dialkyl Phosphonates.” p. 726-727;Synthesis., 1987.
Maffre-Lafon et al.“Solid Phase Synthesis of Phosphonopeptides from Fmoc Phosphonodipeptides.” 35:4097-4098;Tet Lett., 1994.
Maynard et al. “Organophosphorus Compounds II. Preparation of Phosphonic Acid Esters Using the Dicyclohexylcarbodi-Imide Reagent.” 16:609-612;Aust J Chem., 1963.
McKenna et al. “Functional Se

Affiliated with

Also associated with

Rating

Phosphonate inhibitors of HCV does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phosphonate inhibitors of HCV, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phosphonate inhibitors of HCV will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4240021