Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-03-22
2011-03-22
Wilson, James O (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C544S408000, C548S953000, C549S475000
Reexamination Certificate
active
07910747
ABSTRACT:
Pyrazoloamides are provided which are phosphonate and phosphinate glucokinase activators that are useful in treating diabetes and related diseases and have the structurewhereinis a pyrazoyl ring;R4is —(CH2)n—Z—(CH2)m—PO(OR7)(OR8),—(CH2)nZ—(CH2)m—PO(OR7)R9, or—(CH2)nZ—(CH2)m—PO(R9)(R10);R5and R6are independently selected from H, alkyl and halogen;Y is R3(CH2)s, wherein R3is aryl , s is 0, X is a bond; andn, Z, m, R4, R5, R6, and R7are as defined herein;or a pharmaceutically acceptable salt thereof.
REFERENCES:
patent: 6320050 (2001-11-01), Bizzarro et al.
patent: 2006/0135578 (2006-06-01), Momose et al.
patent: 1 074 556 (2001-07-01), None
patent: WO 00/58293 (2000-10-01), None
patent: WO 02/08209 (2002-01-01), None
patent: WO 02/46173 (2002-06-01), None
patent: WO 03/015774 (2003-02-01), None
patent: WO 03/095438 (2003-11-01), None
patent: WO 2004/072031 (2004-08-01), None
patent: WO 2004/072066 (2004-08-01), None
patent: WO2004/013139 (2004-12-01), None
patent: WO 2005/028488 (2005-03-01), None
patent: WO 2005/044801 (2005-05-01), None
patent: WO 2005/054200 (2005-06-01), None
patent: WO 2005/056530 (2005-06-01), None
patent: WO 2005/080359 (2005-09-01), None
patent: WO 2005/080360 (2005-09-01), None
patent: WO 2005/103021 (2005-11-01), None
patent: WO 2005/121110 (2005-12-01), None
patent: WO 2006/016174 (2006-02-01), None
patent: WO 2006/016178 (2006-02-01), None
patent: WO 2006/016194 (2006-02-01), None
patent: WO 2006/040528 (2006-04-01), None
patent: WO 2006/040529 (2006-04-01), None
patent: WO 2006/058923 (2006-06-01), None
patent: WO 2007/007040 (2007-01-01), None
patent: WO 2007/007041 (2007-01-01), None
patent: WO 2007/007042 (2007-01-01), None
patent: WO 2007/017649 (2007-02-01), None
patent: WO 2007/060448 (2007-05-01), None
Jordan, V. C. Nature Reviews: Drug Discovery, 2, 2003, p. 205.
Dörwald, F. Zaragoza. Side Reactions in Organic Synthesis: A Guide to Successful Synthesis Design, Weinheim: WILEY-VCH Verlag GmbH & Co. KGaA, 2005, Preface.
Wermuth, Camille G. The Practice of Medicinal Chemistry—Chapter 13: Molecular Variations Based on Isosteric Replacements, London: Academic Press United, 1996, pp. 203-237.
Fyfe, M. C. T. et al., “Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions”, Diabetologia, 50(6), pp. 1277-1287, (2007).
Guertin, K.R. et al., “Small molecule glucokinase activators as glucose lowering agents: A new paradigm for diabetes therapy”, Current Medicinal Chemistry, 13(15), pp. 1839-1843, (2006).
Johnson, D. et al., “Glucose-dependent Modulation of Insulin Secretion and Intracellular Calcium Ions by GKA50—a Glucokinase Activator”, Diabetes, 56, pp. 1694-1702 (2007).
McKerrecher, D. et al., “Design of a potent, soluble glucokinase activator with excellent in vivo efficacy”, Bioorg. Med. Chem. Lett., 16, pp. 2705-2709 (2006).
Sarabu, R. et al., “Targeting glucokinase activation for the treatment of type 2 diabetes—A status review”, Current Opinion in Drug Discovery and Development, 8(5), pp. 631-637, (2005).
Baboulene, M. et al, “Reactivity of diethyl 3-bromo-2-oxopropyl Phosphonate in the Hantzsch Reaction”, Phosphorus and Sulfur and the Related Elements, Gordon and Breach—Harwood Academic, vol. 5, No. 1, (1978), pp. 87-94.
Endova, M. et al., “Transprotection of n-Benzoylated Nucleobase Derivatives by Dialkylaminomethylene Group”, Nucleosides & Nucleotides, Marcel Dekker, Inc. US., vol. 16, No. 12, (1997), pp. 2151-2164.
Holy, A. et al., “Synthesis of N-(2-Phosphonylmethoxyethyl) Derivatives of Heterocyclic Bases”, Collection of Czechoslovak Chemical Communications, Institute of Organic Chemistry & Biochemistry, Prague, CZ, vol. 54, No. 8, (1989) pp. 2190-2210.
Rosenberg, I. et al., “Acyclic Nucleotide Analogs. IV. Phosphonylmethoxyalkyl and Phosphonylalkyl Derivatives of Adenine”, Collection of Czechoslovak Chemical Communications, Institute of Organic Chemistry & Biochemistry, Prague, CZ, vol. 53, (1988), pp. 2753-2777.
Rumthao, S. et al., “Design, Synthesis, and Evaluation of Oxyanion-hole Selective inhibitor Substituents for the S1 Subsite of Factor Xa”, Bioorganic & Medicinal Chemistry Letters, Oxford, GB, vol. 14, No. 20, (2004), pp. 5165-5170.
Bolton Scott A.
Chen Sean
Cheng Peter T. W.
Meng Wei
Ryono Denis E.
Bristol--Myers Squibb Company
Gibbons Maureen S.
Rodney Burton
Willis Douglas M
Wilson James O
LandOfFree
Phosphonate and phosphinate pyrazolylamide glucokinase... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Phosphonate and phosphinate pyrazolylamide glucokinase..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phosphonate and phosphinate pyrazolylamide glucokinase... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2699788