Phospholipid derivative

Details Phospholipid derivative Phospholipid derivative

2004-03-19

2008-07-15

Eyler, Yvonne (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

Reexamination Certificate

active

07399877

ABSTRACT:
A phospholipid derivative represented by the following formula (I) wherein R1CO and R2CO independently represent an acyl group; R3represents hydrogen atom, or a hydrocarbon group; symbol “a” represents an integer of 0 to 4; symbol “b” represents 0 or 1, provided that when a is 0, b is 0; X represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium; A1O and A3O represent an oxyalkylene group containing oxyethylene group, wherein the ratio of the oxyethylene group to the oxyalkylene group in A1O and A3O is 0.5 or larger in terms of a weight ratio; A2O represents an oxyalkylene group; symbols “m” and “q” represent an average molar number of added oxyalkylene groups; and symbol “n” represent an average molar number of added oxyalkylene groups; provided that m, n and q satisfy the following conditions: 5≦m≦600, 1≦n≦45, 0≦q≦200, 10≦m+n+q≦600, 0.04≦n/(m+n+q), and q/(m+n+q)≦0.8, which can thicken the water shell of liposome surface by suppressing the spreading of the polyalkylene oxide structure on the surface and thus increase stability of the liposome

REFERENCES:
patent: 5142036 (1992-08-01), Akimoto et al.
patent: 5173219 (1992-12-01), Kim
patent: 5395619 (1995-03-01), Zalipsky et al.
patent: 5540935 (1996-07-01), Miyazaki et al.
patent: 5631018 (1997-05-01), Zalipsky et al.
patent: 6344576 (2002-02-01), Eibl
patent: 6436905 (2002-08-01), Tonge et al.
patent: 2002/0147136 (2002-10-01), Von Wronski et al.
patent: 2003/0144247 (2003-07-01), Kuwano et al.
patent: 2005/0220856 (2005-10-01), Itoh et al.
patent: 2006/0110436 (2006-05-01), Ohhashi et al.
patent: 2006/0210618 (2006-09-01), Kubo et al.
patent: 0373621 (1990-06-01), None
patent: 0657463 (1995-06-01), None
patent: 1279406 (2003-01-01), None
patent: 63-221837 (1988-09-01), None
patent: 2-163108 (1990-06-01), None
patent: 6-228012 (1994-08-01), None
patent: 7-242680 (1995-09-01), None
patent: 7-268038 (1995-10-01), None
patent: 9-255740 (1997-09-01), None
patent: 2002-522442 (2002-07-01), None
patent: 99/09955 (1999-03-01), None
patent: 00/08031 (2000-02-01), None
patent: 00/33817 (2000-06-01), None
patent: 01/05375 (2001-01-01), None
patent: 01/74400 (2001-10-01), None
patent: 03/082882 (2003-10-01), None
patent: 2004/029104 (2004-04-01), None
patent: 2004/060899 (2004-07-01), None
English language abstract of JP 63-221837, published Sep. 14, 1988.
English language abstract of JP 2-163108, published Jun. 22, 1990.
English language abstract of JP 6-228012, published Aug. 16, 1994.
English language abstract of JP 7-242680, published Sep. 19, 1995.
English language abstract of JP 7-268038, published Oct. 17, 1995.
English language abstract of JP 9-255740, published Sep. 30, 1997.
English language abstract of JP 2002-522442, published Jul. 23, 2002.
Harish M. Patel et al., “Inhibitory Effect on Cholesterol on the Uptake of Liposomes by Liver and Spleen”, Biochimica et Biophysica Acta, vol. 761, pp. 142-151 (1983).
Carsten F. Gotfredsen et al., “Disposition of Intact Liposomes of Different Compositions and of Liposomal Degradation Products”, Biochemical Pharmacology, vol. 32, No. 22, pp. 3381-3387 (1983).
Pharmaceutical Society of Japan, 106thAnnula Meeting, Summaries of Symposia, pp. 336 (1986).
T.M. Allen et al., “Large Unilamellar Liposomes with Low Uptake into the Reticuloendothelial System”, FEBS Letter, vol. 223, No. 1, pp. 42-46 (1987).
Alexander L. Klibanov et al., “Amphipathic Polyethyleneglycois Effectively Prolong the Circulation Time of Liposomes”, FEBS Letter, vol. 268, No. 1, pp. 235-237 (1990).
Shingo Niimi et al., “Effects of Glucocorticoids on Deoxyribonucleic Acid (DNA) Synthesis Stimulated by Growth Factors in Cultured Rat Skin Fibroblasts”, Chem. Pharm. Bul., vol. 38, No. 6, pp. 1633-1638 (1990).
Yong Serk Park et al., “Some Negatively Charge Phospholipid Derivatives Prolong the Liposome Circulation in Vivo”, Biochimica et Biophysica Acta, vol. 1108, pp. 257-260 (1992).
Database WPI, Section Ch, Week 199546, Derwent Publications Ltd., London, GB, AN 1995-355265, XP002354282; accompanied by family member JP 07-242680 A.
T. Yuda et al., Biological and Pharmaceutical Bulletin, vol. 19, No. 10, pp. 1347-1351, 1996.
R. Zeisig et al., Biochimica et Biophysica Acta, vol. 1285, No. 2, pp. 237-245, 1996.
T.M. Allen et al., Biochimica et Biophysica Acta, vol. 1061, No. 1, pp. 56-64, 1991.

Affiliated with

Also associated with

Rating

Phospholipid derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phospholipid derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phospholipid derivative will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3966388