Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1997-07-14
2000-11-14
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
564 15, A61K 3166, C07F 928
Patent
active
061470619
ABSTRACT:
A compound of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, synergy with cytotoxic anticancer agents, tissue ulceration, macular degeneration, restenosis, periodontal disease, epidermolysis bullosa, scleritis, in combination with standard NSAID'S and analgesics and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic shock and other diseases involving the production of TNF. In addition, the compounds of the present invention may be used in combination therapy with standard non-steroidal anti-inflammatory drugs (NSAID'S) and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinim, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer.
REFERENCES:
patent: 4885283 (1989-12-01), Broadhurst et al.
International Search Report-PCT/IB 97/00800, 1997.
Murphy et al., Current Medicinal Chemistry, 2, pp. 743-762 (1995).
Makonkawkeyoon, et al., Proc. Natl. Acad. Sci., 90 (13), 5974 (1993).
Djuardi Elsa
Ginsburg Paul H.
Pfizer Inc.
Raymond Richard L.
Richardson Peter C.
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