Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Stablizing an enzyme by forming a mixture – an adduct or a...
Patent
1996-05-29
1998-08-04
Ceperley, Mary E.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Stablizing an enzyme by forming a mixture, an adduct or a...
435174, 435176, 435181, 436500, 436518, 436532, 5303911, 5303915, 530811, 530816, C12N 1114, C12N 1106, C12N 1108, C07K 1706
Patent
active
057892199
ABSTRACT:
The present invention provides crosslinking, conjugating and reducing agents which are functional with at least one phosphorothioate monoester group (--SPO.sub.3.sup.-2). Crosslinking and conjugation methods as well as solid phase reagents and conjugates which are useful in immunoassays are also provided.
Crosslinking and conjugating agents of the invention generally comprise a compound corresponding to the formula (I), shown below, wherein n at least 1 and Q is a straight or branched monomer, polymer or oligomer having an average molecular weight between about 200 and about 1,000,000. Additionally, when n is 1, Q comprises at least 1 additional reactive functionality.
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Bieniarz Christopher
Cornwell Michael J.
Husain Mazhar
Skrzypczynski Zbigniew
Young Douglas F.
Abbott Laboratories
Anderson Regina M.
Ceperley Mary E.
Levis John F.
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