Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-01-01
2008-01-01
Ulm, John (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S069100, C435S069700, C435S252300, C435S320100, C530S350000, C536S023400, C536S023500
Reexamination Certificate
active
07314725
ABSTRACT:
The invention provides isolated nucleic and amino acid sequences of a taste cell receptor that serves as a sensor for the bitter taste of phenylthiocarbamide (PTC), antibodies to such PTC taste receptor, methods of detecting such nucleic and amino acid sequences, and methods of screening for modulators of such PTC taste receptor.
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Reed D. R. et al., “Localization of a gene for bitter—taste perception human chromosome 5p15,”American J. of Human Genetics, 64:1478-1480, 1999.
Guo and Reed, “The genetics of phenylthiocarbamide perception,”Annals of Human Biology28(2): 111-142, 2001.
Kim et al., “Positional Cloning of the Human Quantitative Trait Locus Underlying Taste Sensitivity to Phenylthiocarbamide,”Science299: 1221-1225, 2003.
Matsunami et al., “A family of candidate taste receptors in human and mouse,”Nature404: 601-604, 2000.
McLaughlin et al., “Gustducin is a taste-cell-specific G protein closely related to the transducins,”Nature357: 563-569, 1992.
Miyajima et al., “Expression of murine and human granulocyte-macrophage colony—stimulating factors inS. cerevisiae: mutagenesis of the potential glycosylation sites,”EMBO J5: 1193-1197, 1986.
Offermans and Simon, “Gα15 and Gα16 couple a wide variety of receptors to phospholipase C,”J. Biol. Chem.270: 15175-15180, 1995.
Shi et al, “Adaptive Diversification of Bitter Taste Receptor Genes in Mammalian Evolution,”Mol. Biol. Evol.20:805-814, 2003.
Sulston and Waterston, “Toward a complete human genome sequence,”Genome Research8: 1097-1108, 1998.
Vaidehi et al., “Prediction of structure and function of G protein-coupled receptors,”PNAS99: 12622-12627, 2002.
Wooding et al., “Natural Selection and Molecular Evolution in PTC,
Drayna Dennis
Kim Un-Kyung
Leppert Mark
Klarquist & Sparkman, LLP
The United States of America as represented by the Secretary of
Ulm John
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