Phenylpropionic acid derivatives

Details Phenylpropionic acid derivatives Phenylpropionic acid derivatives

2007-03-20

2007-03-20

Witherspoon, Sikarl A. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C562S450000, C514S183000, C514S506000, C514S554000, C514S580000, C514S613000

Reexamination Certificate

active

10763237

ABSTRACT:
Specified phenylpropionic acid derivatives and analogues thereof have an antagonistic activity to α 4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning α 4 integrin, such as inflammatory diseases in which α 4 integrin-depending adhesion process participates in the pathology, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.

REFERENCES:
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patent: WO 99/10313 (1999-03-01), None
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patent: WO 00/05223 (2000-02-01), None
U.S. Appl. No. 10/866,260, filed Jun. 14, 2004, Okuzumi et al.
U.S. Appl. No. 10/921,929, filed Aug. 20, 2004, Sagi et al.

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