Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-06-12
2008-11-25
Bernhardt, Emily (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S254090, C544S368000, C544S373000
Reexamination Certificate
active
07456182
ABSTRACT:
The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D2receptor and/or the serotonin reuptake site, and the ability to treat conditions related to disturbances in the dopaminergic and/or the serotonergic systems such as anxiety disorders, depression, Parkinson's disease, and schizophrenia.The invention relates to a group of novel phenylpiperazine derivatives of the formula (I):wherein:X is a group of formula 1, 2, 3, 4, 5, 6, or 7 as defined in the text,m has the value 2 to 6;n has the value 0-2;R5and R6are independently H or alkyl (1-3C); or R5+R6represent a group —(CH2)—pwherein p has the value 3-5, andR7is alkyl (1-3C), alkoxy (1-3C), halogen or cyano; or R6+R7(R7at position 7 of the indole group) represent a group —(CH2)qwherein q has the value 2-4, and salts thereof.
REFERENCES:
patent: 6828325 (2004-12-01), Feenstra et al.
Kruse Cornelis G.
Tipker Jacobus
Tulp Martinus T. M.
Van der Heijden Johannes A. M.
Van Hes Roelof
Bernhardt Emily
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
Solvay Pharmaceuticals, Inc.
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