Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-01-02
2007-01-02
Chang, Celia (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S369000, C548S200000, C548S541000
Reexamination Certificate
active
10481352
ABSTRACT:
The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
REFERENCES:
patent: 4386090 (1983-05-01), Moinet et al.
patent: 5556941 (1996-09-01), Kolar et al.
patent: 5939560 (1999-08-01), Jenkins et al.
patent: 6015812 (2000-01-01), Ferrari et al.
patent: 2004/0121965 (2004-06-01), Greenberger et al.
patent: 2004/0176428 (2004-09-01), Edmondson et al.
patent: WO 97/40832 (1997-11-01), None
patent: WO 98/19998 (1998-05-01), None
patent: WO 98/19998 (1998-05-01), None
patent: WO 00/34241 (2000-06-01), None
patent: WO 01/34594 (2001-05-01), None
patent: WO 01/42262 (2001-06-01), None
patent: WO 01/96295 (2001-12-01), None
patent: WO 01/96295 (2001-12-01), None
patent: WO 02/02560 (2002-01-01), None
patent: WO 02/02560 (2002-01-01), None
patent: WO 03/000180 (2003-01-01), None
patent: WO 03/000180 (2003-01-01), None
patent: WO 03/000181 (2003-01-01), None
patent: WO 03/000181 (2003-01-01), None
patent: WO 03/004498 (2003-01-01), None
patent: WO 02/076450 (2003-10-01), None
patent: WO 03/082817 (2003-10-01), None
STN results.
STN results.
CAS registry No. 676637-07-3 in Document No. 140:304081.
McIntosh et al., Dipeptidyl Peptidase IV Inhibitors: How do they Work as new Antidiabetic Agens?, Regulatory Peptides, 128:159-165 (2005).
Deacon & Holst, Dipeptidyl Peptidase IV Inhibitors: A Promising New Therapeutic Approach for the Management of Type 2 Diabetes, INT. J. Biochem. & Cell Bio., 38:831-844 (2006).
Expert Opinion onTherapeutic Patents, “Novel N-substituted-2-cyanopyrrolidines as potent inhibitors of dipeptidyl peptidase IV in the treatment of non-insulin-dependent diabetes mellitus”, vol. 10 (#12) p. 1937-1942 (2000).
Expert Opinion on Investig. Drugs, “Gut peptides in the treatment of diabetes mellitus”, (2004) 13 (3) 177-188.
Expert Opinion on Investig. Drugs, “Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes”, (2003) 12:87-100.
Expert Opinion on Therapeutic Patents, “Dipeptidyl peptidase IV inhibitors as new therapeutic agents for the treatment of Type 2 diabetes”, (2003) 13: 499-510.
Colandrea Vincent J.
Edmondson Scott D.
Mastracchio Anthony
Mathvink Robert J.
Weber Ann E.
Balls R. James
Chang Celia
Durette Philippe L.
Merck & Co. , Inc.
Winokur Melvin
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