Phenylalanine derivatives as dipeptidyl peptidase inhibitors...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S369000, C548S200000, C548S541000

Reexamination Certificate

active

10481352

ABSTRACT:
The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

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STN results.
STN results.
CAS registry No. 676637-07-3 in Document No. 140:304081.
McIntosh et al., Dipeptidyl Peptidase IV Inhibitors: How do they Work as new Antidiabetic Agens?, Regulatory Peptides, 128:159-165 (2005).
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Expert Opinion on Therapeutic Patents, “Dipeptidyl peptidase IV inhibitors as new therapeutic agents for the treatment of Type 2 diabetes”, (2003) 13: 499-510.

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