Phenyl-piperazine derivatives as serotonin reuptake inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C546S339000, C546S236000, C544S395000, C540S575000, C540S611000, C514S212010, C514S218000, C514S255030, C514S317000

Reexamination Certificate

active

07138407

ABSTRACT:
The invention provides compounds represented by the general formula Iwherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.

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Lawrence L. Martin, et al. “Synthesis of Spiro[Isobenzofur4an-1(3 H), 4′-piperidines] as Potential Central Nervous System Agents. 5. Conformationally Mobile Analogues Derived by Furan Ring Opening”, Journal of Medicinal Chemistry, 1979, vol. 22, No. 11.

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