Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2005-05-09
2008-11-11
Kumar, Shailendra (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C564S153000, C558S052000, C558S415000, C514S518000, C514S522000, C514S616000
Reexamination Certificate
active
07449599
ABSTRACT:
The present invention is directed to phenyl carboxamide compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
REFERENCES:
patent: WO 96/08483 (1996-03-01), None
patent: WO 03/106405 (2003-12-01), None
patent: WO 2005/005374 (2005-01-01), None
Craig A. Coburn et al., “Identification of a Small Molecule Nonpeptide Active Beta-Secretase . . . ,” J. Med. Chem., vol. 47, pp. 6117-6119 (2004).
Shawn J. Stachel et al., “Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human Beta-Secretase (BACE-1),” J. Med. Chem., vol. 47, pp. 6447-6450 (2004).
Annis, Jr. David Allen
Coburn Craig A.
Makara Gergely M.
Nash Huw M.
Steele Thomas G.
Krovatin William
Kumar Shailendra
Merck & Co Inc.
Todaro John C.
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