Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-11-30
1990-06-26
Lee, Mary C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546233, 546238, 546240, C07D21118, C07D21132, C07D21154, C07D21122
Patent
active
049373463
ABSTRACT:
Compound of the formula ##STR1## wherein n is 1 or 2, Y is OH, R.sup.1 COO--, R.sup.2 R.sup.3 NCOO-- or R.sup.4 O whereby R.sup.1 is an alkyl group, or a possibly substituted phenyl group, R.sup.2 is an alkyl, phenethyl, or benzyl or phenyl group, R.sup.3 is H or an alkyl group and R.sup.4 is an allyl or benzyl group, and R is an alkyl, hydroxyalkyl, dimethylaminoalkyl or methylthioalkyl group or alkenyl group, processes for their preparations and methods of treatment employing such compounds. The compounds are useful for therapeutic purposes, especially for treatment of disorders in the central nervous system.
REFERENCES:
patent: 2892842 (1959-06-01), McElvain
patent: 4426386 (1984-01-01), Arvidsson et al.
Roberts, et al., Basic Principles of Organic Chemistry, 2nd Ed., W. A. Benjamin, Inc., Menlo Park, Calif., (1977).
Bulletin de la Societe Chimique de France, 1968, No. 3, pp. 1000-1007.
J. Med. Chem., 1981, 24, pp. 1475-1482.
Arvidsson Folke L.
Carlsson Per A. E.
Hacksell Uli A.
Hjorth John S. M.
Lindberg Per L.
Carlsson Per Arvid Emil
Lee Mary C.
Whittenbaugh Robert C.
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