Phenoxyethylamine derivatives, for preparing the same and compos

Details Phenoxyethylamine derivatives, for preparing the same and compos Phenoxyethylamine derivatives, for preparing the same and compos

1989-01-24

1990-11-20

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514601, 514602, 514603, 548542, 564 84, 564 86, 564 90, C07C14378, C07C14712, A61K 3118, A61K 3140, C07D20712

Patent

active

049719904

ABSTRACT:
Phenoxyethylamine derivatives represented by the general formula (I): ##STR1## wherein R.sub.1 and R.sub.5 represent lower-alkyl, R.sub.2 and R.sub.3, which may be the same or different, each represents hydrogen or lower-alkyl, or ##STR2## represents a 5- or 6-membered ring system which may include nitrogen, oxygen or sulfur as a ring membered atom, R.sub.4 represents hydrogen or lower-alkyl, and n represents an integer selected from 1 to 3, their optical isomers and pharmacologically-acceptable acid addition salts, which exhibit excellent .alpha..sub.1 -blocking activity, a process for their preparation, pharmaceutical compositions thereof, and a method for the treatment of a subject afflicted with hypertension or dysuria by administrating such a compound, are all disclosed.

REFERENCES:
J. Pharmacol. Exp. Ther. 239, 512 (1986).
J. Pharmacol. Exp. Ther. 236, 776 (1986).
J. Pharmacol. Exp. Ther. 235, 764 (1985).
J. Pharm. Pharmacol. 39, 316 (1987).
J. Pharm. Pharmacol. 36, 539 (1984).
Jpn. J. Pharmacol. 42, 579 (1986).
Jpn. J. Pharmacol. 41, 459 (1986).
Jpn. J. Pharmacol. 42, 237 (1986).
Naunyn-Schmiedeberg's Arch. Pharmacol. 328, 264 (1985).

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