Phenoxy-hydroxypropylamines, their preparation, and method and p

Details Phenoxy-hydroxypropylamines, their preparation, and method and p Phenoxy-hydroxypropylamines, their preparation, and method and p

1974-01-15

1976-12-21

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260307C, 260348R, 260471C, 26050117, 26050119, 260516, 260521R, 260553A, 2605709, 260544N, 424300, 424316, 424330, C07C 9306

Patent

active

039987906

ABSTRACT:
Para-substituted phenoxy-hydroxypropylamines having the general formula ##STR1## and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R' is an isopropyl or tertiarybutyl radical; Z is a member selected from the group consisting of -OR", -SR", and -NHCOOR", R" being a straight or branched lower alkyl radical having 1 to 3 carbon atoms; and n is 1, 2, or 3, are disclosed as are methods for their preparation. Pharmaceutical preparations are prepared whose active ingredients include at least one of the newly discovered phenoxy-hydroxypropylamine compounds. Therapeutically effective doses of these preparations selectively block the .beta.-receptors of the heart making them useful in treating heart diseases in animals including humans.

REFERENCES:
patent: 3203992 (1965-08-01), Kunz et al.
patent: 3541130 (1970-11-01), Koppe et al.
patent: 3631108 (1971-12-01), Brandstrom et al.
patent: 3755413 (1973-08-01), Koppa et al.
Ciba, "Chemical Abstracts", vol. 66, p. 6129. (1967).

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