Phenanthridine derivatives and compositions containing them

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

546 61, 536 173, 536 174, C07D22118, A61K 31435

Patent

active

049391585

ABSTRACT:
The invention relates to 1,8-dihydroxy-3-methylbenz[b]phenanthridine-7,12-dione and its derivatives of formula I ##STR1## wherein R.sup.1 is hydrogen or the radical of formula II ##STR2## and salts of the compound, wherein R.sup.1 is the radical of formula II. These compounds can be obtained by means of a novel microbiological process and used for the therapeutic treatment of tumors.

REFERENCES:
Israel et al., Chem. Abs., vol. 105, entry#24506g (1986).
MPEP 608.01 (p) Subject C, "Suggestion for Deposit of Biological Material".
Klemm et al., "Synthesis of Benzo [b] and Benzo[j] Phenanthndines", Journ. Het. Chem., vol. 2, No. 1, pp. 15-20 (1965).
Arlandini et al., "Interaction of New Deriv. of Daunorubicin", Il Farmaco Ed. Sci., vol. 32 (5) pp. 315-323, (1977).
Khokhlov et al., Chem. Abstr., vol. 103: 14223u (1985).

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