Pharmaceutically active combination

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases

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424 9463, 514 2, 514 12, A61K 37547, A61K 3702

Patent

active

051261340

ABSTRACT:
There is provided a pharmaceutical composition comprising as component A a plasminogen activator and as component B hirudin together with a pharmaceutically acceptable carrier. The pharmaceutical composition can be used for the prophylaxis and therapy of thrombosis or diseases caused by thrombosis.

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F. Markwardt, Cardiovascular Pharmacology (1987) J. Gy. Papp (ed)-pp. 449-456.
Tamao et al., Thrombosis and Haemostasis 56(1), 28-34, (1986).
Markwardt et al., Thrombosis and Haemostasis 47(3), 226-229 (1982).
Rijken et al., Bioichem. J. (1986), 238, 643-646.
Van Zonneveld et al., J. Cell. Biochem. 32:169-178 (1986).
Ehrlich et al., Fibrinolysis, vol. 1, No. 2 (1987) pp. 75-82.
Haber et al., Science, vol. 243 (Jan. 6, 1989), pp. 51-56.

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