Medical electrical lead having improved fixation

Surgery: light – thermal – and electrical application – Light – thermal – and electrical application – Electrical energy applicator

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607126, 600375, A61N 105

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active

060788402

ABSTRACT:
The present invention is directed to a medical electrical lead having active fixation which features an improved fixation helix. In particular the present invention is a medical electrical lead having a fixation helix which features microgrooves. The microgrooves are dimensioned so as to minimize the foreign body response of the tissue into which the helix is implanted. The microgrooves preferably consist of a series of grooves parallel to the longitudinal axis of the helix, each groove has a depth of between approximately 0.1 to 30 microns, preferably between approximately 0.1 and 3, with 1 micron preferred; a width of between approximately 0.1 to 30 microns, preferably between approximately 0.1 and 3, with 1 micron preferred; and is spaced apart from every other groove by a distance of between approximately 0.1 to 30 microns, preferably between approximately 0.1 and 3, with 1 micron preferred. Although shown as square, the grooves may be of any shape, including rectangular, polygonal, rounded or even irregularly shaped.

REFERENCES:
patent: 5002067 (1991-03-01), Berthelsen et al.
patent: 5011494 (1991-04-01), von Recum et al.
patent: 5318572 (1994-06-01), Helland et al.
"Quantitative Analysis of Fibroblast Morphology on Microgrooved Surfaces with Various Groove and Ridge Dimensions" -- E.T. den Braber et al. (Biomaterials 1996, vol. 17 No. 21, pp. 2037-2044).
"Effect of Parallel Surface Microgrooves and Surface Energy on Cell Growth" -- E.T. den Braber et al. (Journal of Biomedical Materials Research, vol. 29, 1995, pp. 511-518).
"Soft Tissue Response to Different Types of Sintered Metail Fibre-web Materials" -- J.A. Jansen et al. (Biomaterials 1992, vol. 13, No. 13, pp. 959-968).
"Quantitative Analysis of Cell Proliferation and Orientation on Substrate with Uniform Parallel Surface Micro-grooves" -- E.T. den Braber et al. (Biomaterials 1996, vol. 17, No. 11, pp. 1093-1099).
"Fibroblast Anchorage to Microtextured Surfaces" -- J. Meyle et al. (Journal of Biomedical Materials Research, vol. 27, 1993, pp. 1553-1557).

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