Pharmaceutical preparation of recombinant factor VIII...

Details Pharmaceutical preparation of recombinant factor VIII... Pharmaceutical preparation of recombinant factor VIII...

2005-05-03

2005-05-03

Wax, Robert A. (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S383000, C435S069600

Reexamination Certificate

active

06887852

ABSTRACT:
Disclosed is a lyophilized preparation of recombinant factor VIII used as a therapeutic preparation of hemophilia A. The lyophilized preparation of recombinant factor VIII is prepared by performing lyophilization using a mixture comprising 6 to 100 mM of L-arginine, 3.5 to 50 mM of L-isoleucine, and 10 to 100 mM of L-glutamic acid as a stabilizer for stabilizing the recombinant factor VIII which exhibits an unstable activity during lyophilization, rather than using human blood derived albumin.

REFERENCES:
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patent: 0 077 870 (1983-05-01), None
patent: 0 268 110 (1988-05-01), None
patent: WO-8909614 (1989-10-01), None
patent: WO-9110439 (1991-07-01), None
patent: WO 9322336 (1993-11-01), None
patent: WO 96-22107 (1996-07-01), None
patent: WO-9622107 (1996-07-01), None

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