Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...
Reexamination Certificate
2006-06-27
2006-06-27
Devi, S. (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fungus, except allergen, or component thereof or substance...
C424S184100, C424S185100, C530S350000, C530S300000, C530S824000, C530S806000, C514S002600
Reexamination Certificate
active
07067138
ABSTRACT:
ACandida albicansbloodstream infections cause significant morbidity and mortality in hospitalized patients. Filament formation and adherence to host cells are critical virulence factors ofC. albicans. Multiple filamentation regulatory pathways have been discovered, however the downstream effectors of these regulatory pathways remain unknown. The cell surface protein, Als1p, is a downstream effector of the filamentation regulatory pathway and is regulated by Efg1p. Als1p mediates adherence to endothelial cells in vitro and is required for virulence. The blocking of adherence by the organism is described resulting from the use of a composition and method disclosed herein. Specifically, a pharmaceutical composition comprised of a gene product from the ALS1 gene family is administered as a vaccine to generate an immune response capable of blocking adherence of the organism.
REFERENCES:
patent: 5668263 (1997-09-01), Hoyer et al.
patent: 5817466 (1998-10-01), Hoyer et al.
patent: 6747137 (2004-06-01), Weinstock et al.
Hoyer et al. J. Bacteriol. 180 (20): 5334-5343, Oct. 1998.
Harlow et al. In: Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory, Chapter 5, p. 76, 1988.
Kraus et al. J. Immunol. 139: 3084-3090, 1987.
Barki, M., Y. Koltin, M. Yanko, A. Tamarkin, and M. Rosenberg. 1993. Isolation of aCandida albicansDNA sequence conferring adhesion and aggregation onSaccharomyces cerevisiae.J. Bacteriol. 175:5683-5689.
Bendel, C. M. and M. K. Hostetter. 1993. Distinct Mechanisms of Epithelial Adhesionfor Candida albicans and Candida tropicalis.J. Clin. Invest. 92:1840-1849.
Caesar-TonThat, T. C. and J. E. Cutler. 1997. A monoclonal antibody toCandida albicansenhances mouse neutrophil candidacidal activity. Infect. Immun. 65:5354-5357.
Castaldo, P., R. J. Stratta, R. P. Wood, and et al. 1991. Clinical spectrum of fungal infections after orthotopic liver transplantation. Arch. Surg. 126:149-156.
Cutler, J. E., D. L. Brawner, K. C. Hazen, and M. A. Jutila. 1990. Characteristics ofCandida albicansadherence to mouse tissues. Infect. Immun. 58:1902-1908.
De, Bernardis, F., M. Boccanera, D. Adriani, E. Spreghini, G. Santoni, and A. Cassone. 1997. Protective role of antimannan and anti-aspartyl proteinase antibodies in an experimental model ofCandida albicansvaginitis in rats. Infect. Immun. 65:3399-3405.
Dromer, F., J. Charreire, A. Contrepois, C. Carbon, and P. Yeni. 1987. Protection, of mice against experimental cryptococcosis byanti-cryptococcus neoformansmonoclonal antibody. Infect. Inimun. 55:749-752.
Ekenna, O., R. J. Sherertz, and H. Bingham. 1993. Natural history of bloodstream infections in a burn patient population: the importance of candidernia. Am. J. Infect. Control. 21:189-195.
Fisher-Hoch, S. P. and L. Hutwagner. 1995. Opportunistic candidiasis: an epidemic of the 1980's. Clin. Infect. Dis. 21:897-904.
Fonzi, W. A. and M. Y. Invin. 1993. Isogenic strain construction and gene mapping inCandida albicans.Genetics 134:717-728.
Fu, Y., S. G. Filler, B. J. Spellberg, W. Fonzi, A. S. Ibrahim, T. Kanbe, M. A. Ghannoum, and J. E. J. Edwards. 1998. Cloning and characterization of CAD I/AAF1, a gene fromCandida albicansthat induces adherence to endothelial cells after expression inSaccharomyces cerevisiae.Infect. Immun. 1998, 66:2078-2084.
Fu, Y., A. S. Ibrahim, W. Fonzi, X. Zhou, C. F. Ramos, and M. A. Ghannourn. 1997. Cloning and characterization of a gene (LIPI) which encodes a lipase from the pathogenic yeastCandida albicans.Microbiology. 1997 143:331-340.
Fu, Y., G. Rieg, W. A. Forizi, P. H. Belanger, J. E. J. Edwards, and S. G. Filler. 1998. Expression of theCandida albicans gene ALSI in Saccharomyces cerevisiaeinduces adherence to endothelial and epithelical cells. Infect. Immun. 66:1783-1786.
Gale, C., D. Finkel, N. Tao, 1%1. Meinke, M. McClellan, J. Olson, K. Kendrick, and M. Hostetter. 1996. Cloning and expression of a gene encoding an integrin-like protein inCandida albicans.Proc. Nad. Acad. Sci. U. S. A. 93:357-361.
Gale, C. A., C. M. Bendel, M. McClellan, M. Hauser, J. M. Becker, J. Berman, and K. Hostetter. 1998. Linkage of adhesion, filamentous growth, and virulence inCandida albicansto a single gene, INT1. Sci. 279:1355-1358.
Gaur, N. K. and S. A. Klotz. 1997. Expression, cloning, and characterization of aCandid albicansgene, AL41, that confers adherence properties uponSaccharomyces cerevisiaefor extracellular matrix proteins. Infect. Immun. 65:5289-5294.
Gietz, R. D., R. H. Schiestl, A. R. Willems, and R. A. Woods. 1995. Studies on the transformation of intact yeast cells by the LiAc/SS-DNA/PEG procedure. Yeast. 11 :355-360.
Gustafson, K. S., G. M. Vercellotti, C. M. Bendel, and M. K. Hostetter. 1991. Molecular mimicry inCandida albicans.Role of an integrin analogue in adhesion of the yeast to human endothelium. J. Clin. Invest. 87:1896-1902.
Han, Y. and J. E. Cutler. 1995. Antibody response that protects against disseminated candidiasis. Infect. Immun. 63:2714-2719.
Hasenclever, H. F. and W. O. Mitchell. 1960. Antigenic relationships ofTorulopsis glabrataand seven species of the genusCan&da.J. Bacteriol. 79:677-681.
Hoyer, L.L. 1997. The ALS gene family ofCandida albicans.International Society for Human and Animal Mycology Salsimorge, Italy:(Abstract).
Hoyer, L. L., S. Scherer, A. R. Shatzman, and G. P. Livi. 1995.Candida albicans ALSI: domains related to aSaccharonzyces cerevisiaesexual agglutinin separated by a repeating motif. Mol. Microbiol. 1995, 15:39-54.
Jaffe, E. A., R. L. Nachman, C. G. Becker, and C. R. Ninick. 1973. Culture of human endothelial cells derived. from umbilical veins: identification by morphologic, and immunologic criteria. J. Clin. Invest. 52:2745-2756.
Jarvis, W.R. and H. and the National Nosocomial Infections Surveillance System. 1991. Predominant pathogens in hospital infection. 17th Internat'l Congress Chemoth (Abstract).
Jimenez-Lucho, V., V. Ginsburg, and H. C. Krivan. 1990.Cryptococcus neoformans, Candida albicans,and other fungi bind specifically to the glycosphingolipid lactosylceramide (Ga1P1-4G1cP1-1Cer), a possible adhesion receptor for yeasts. Infect. Immun. 58:2085-2090.
Kim, J. A.9 M. C. Territo, E. Wayner, T. M. Carlos, F. Parhami, C. W. Smith, M. E. Haberland, A. M. Fogellman, and J. A. Berliner. 1994. Partial characterization of leukocyte binding molecules on endothelial cells induced by minimally oxidized LDL. Arterioscler. Thromb. 14:427-433.
Klein, B. S. 1997. Role of cell surface molecules ofBlastomyces dernzatitidisin the pathogenesis and inimunobiology of blastomycosis. Semin. Respir. Infect. 12:198-205.
Klotz, S. A., R. L. Smith, and B. W. Stewart. 1992. Effect of an arginine-glycineaspartic acid-containing peptide on hematogenous candidal infections in rabbits. Antimicrob. Agents Chemother. 36:132-136.
Lipke, P. N., D. Wojciechowicz, and J. Kurjan. 1989. AG alpha I is the structural gene for theSaccharomyces cerevisiaealpha-agglutinin, a cell surface glycoprotein involved in cell-cell interactions during mating. Mol. Cell Biol. 9:3155-3165.
Lotter, H., T. Zhang, K. B. Seydel, S. L. J. Stanley, and E. Tannich. 1997. Indentification of an epitope on theEntamoeba histolytica170-kD lectin conferring antibody-mediated protection against invasive amebiasis. J. Exp. Med. 185:1793-1801.
Manjarrez-Hernandez, A., S. Gavilanes-Parra, M. E. Chavez-Berrocal, J. MolinalLopez, and A. Cravioto. 1997. Binding of diarrheagenicEscherichia colito 32- to 33kilodalton human intestinal brush border proteins. Infect. Immun. 65:4494-4501.
Mayer, C. L., R. D. Diamond, and J. E. Edwards, Jr. 1990. Recognition of binding sites onCandida albicansby monoclonal antibodies to human leukocyte antigens. Infect. Immun. 58:3765-3769.
Mayer, C. L., S. G. Filler, and J. E. Edwards, Jr. 1992.Candida albicansadherence to endothelial cells. Microvasc. Res. 43:218-226.
Mukherjee, J., M. D. Scharff, and A. Casadevall. 1992. Protective murine monoclonal antibodies toCryptococcus neoformas. Infect. Immun. 60:4534-4541.
Palaszynski, S., J. Pinkner, S. Leath, P. Barren, C. G. Auguste, J. Burlein, S. J. Hultgren, and S. Langermann. 1998. Systemic immun
Edwards, Jr. John E.
Filler Scott G.
Fu Yue
Ibrahim Ashraf S.
Sheppard Donald C.
Devi S.
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical
Orrick Herrington & Sutcliffe LLP
LandOfFree
Pharmaceutical compositions and methods to vaccinate against... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmaceutical compositions and methods to vaccinate against..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical compositions and methods to vaccinate against... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3678338