Pharmaceutical composition for treatment of diabetes and...

Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...

Reexamination Certificate

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C424S769000, C514S007400, C514S006800

Reexamination Certificate

active

07959954

ABSTRACT:
A bioactive fraction obtained fromXylocarpusthat is useful for the treatment of diabetes and dyslipidemia. This fraction can be provided in a pharmaceutical composition that is useful as antidiabetic and antidyslipidemic agent, or can be used in a method of treating diabetes and dyslipidemia in a subject. Also, a process for the preparation of bioactive fraction fromXylocarpus. Isomeric xyloccensins and the preparation of such compounds. Also, pharmaceutical compositions comprising a therapeutically effective amount of such isomeric xyloccensins optionally along with one or more pharmaceutically acceptable carriers, additives, lubricant and diluents and the use of such pharmaceutical compositions in a method for treating dyslipidemia.

REFERENCES:
patent: 4675188 (1987-06-01), Chu
patent: 2001/0055627 (2001-12-01), Guthrie et al.
patent: 2002/0198796 (2002-12-01), White et al.
patent: 1513853 (2004-07-01), None
patent: 2000072684 (2000-03-01), None
patent: WO 02/077761 (2002-10-01), None
Uddin et al, Antidiarrhoeal activity of the methanol extract of the barks ofXylocarpus moluccensisin castor oil-and magnesium sulphate-induced diarrhea models in mice, Journal of Ethnopharmacology 101 (2005) 139-143.
Saxena et al, Constituents ofCarapa granatumfruits, Fitoterapia 72 (2001) 186-187.
Mulholland et al, Limonoids from Australian members of the meliaceae, Phytochemistry, 31 (12): 4163-4166, 1992), and further in view of Chu (US 4,675,188.
Kudo et al, The structure of xylomollin, a secoiridoid hemiacetal acetal, Journal of the American Chemical Society 98 (21) 6704-6705, 1976.
Xiao et al, Xyloccensin K extracted fromXylocarpus granatum(muguodong) studied by NMR spectroscopy, Bopuxue Zazhi (2005), 22 (3), 315-319.
Alvi, Limonoids from the Fijian medicinal plant dabi (Xylocarpus), Tdtrahedron 47 (43): 8943-8948, 1991.

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