pH-sensitive methacrylic copolymers and the production thereof

Details pH-sensitive methacrylic copolymers and the production thereof pH-sensitive methacrylic copolymers and the production thereof

2006-02-14

2006-02-14

Pezzuto, Helen L. (Department: 1713)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Polymers from only ethylenic monomers or processes of...

C528S277000, C528S279000, C528S310000, C528S317000, C528S332000, C528S331000

Reexamination Certificate

active

06998456

ABSTRACT:
The present invention provides novel multi-functional methacrylic copolymers that exhibit cationic pH-sensitive behavior as well as good water solubility under acidic conditions. The copolymers are constructed from tertiary amine methacrylates and poly(ethylene glycol) containing methacrylates. The copolymers are useful as gene vectors, pharmaceutical carriers, and in protein separation applications.

REFERENCES:
patent: 4060678 (1977-11-01), Steckler
patent: 5407581 (1995-04-01), Onodera et al.
patent: 2004/0127391 (2004-07-01), Claesson et al.
Deshpande et al. Macromolecules, 32(6), 2088-2090, 1999.
Hariharan et al. Polymer, 37(1), 149-161, 1996.

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