PGC-1 isoforms and uses therefor

Details PGC-1 isoforms and uses therefor PGC-1 isoforms and uses therefor

2007-07-31

2007-07-31

Saidha, Tekchand (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S189000, C435S320100, C536S023100, C536S023200

Reexamination Certificate

active

10482094

ABSTRACT:
The invention provides isolated nucleic acid molecules, designated PGC-1band PGC-1cnucleic acid molecules, which encode novel isoforms of PGC-1 family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

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