Perfluoro-t-butyl-containing compounds for use in fluorine-19 NM

Details Perfluoro-t-butyl-containing compounds for use in fluorine-19 NM Perfluoro-t-butyl-containing compounds for use in fluorine-19 NM

1991-09-19

1993-08-10

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

435 4, 435 13, 436173, 324300, 1286534, 564366, 514 12, 514654, 514743, 514759, 514832, G01N 2408, G12Q 156, A61K 3700, C07C21100

Patent

active

052346803

ABSTRACT:
The present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The perfluoro-t-butyl (PFTB) moiety, ##STR1## is an excellent reporter group for fluorine-19 NMR/MRI. It is a source of nine magnetically equivalent fluorine nuclei which generate a single intense resonance for easy detection in spectroscopy or imaging. This signal is a sharp singlet, not split by neighboring nuclei or spread over a wide frequency range and eliminates any chance of ghost images which might arise from multiple resonances. These spectral properties ensure a maximum signal-to-noise ratio (S/N) for readily detecting this moiety. The foregoing allows either reduction in the concentration of the derivatized compound, ability to use MRI instruments with lower field strengths, a reduction in imaging times, or a combination of the foregoing as a result of this moiety producing a single, sharp, intense resonance.
Additionally, the PFTB moiety-containing compounds may be utilized to determine oxygen concentration in aqueous solutions present in animate and inanimate objects.

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