Percutaneous-administration-type pharmaceutical preparation of n

Details Percutaneous-administration-type pharmaceutical preparation of n Percutaneous-administration-type pharmaceutical preparation of n

1991-04-04

1993-11-09

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, 424443, 424447, A61F 1302

Patent

active

052600645

ABSTRACT:
A percutaneous-administration-type pharmaceutical preparation of nitroglycerin is provided. The preparation comprises a backing that is impervious to medicines, and a pressure-sensitive adhesive layer that is placed on one surface of said backing, wherein said pressure-sensitive adhesive layer contains an alkyl (meth)acrylate (co)polymer in the concentration of 35-85% by weight, nitroglycerin in the concentration of 10-30% by weight, and a silicic acid anhydride in the concentration of 5-20% by weight, said (co)polymer contains as major (co)polymer components alkyl (meth)acrylates with alkyl groups having 6 or more carbon atoms, which alkyl (meth)acrylates include 2-ethylhexyl methacrylate in the concentration of 40-100% by weight based on the total weight of said alkyl (meth)acrylates. The preparation makes it possible for nitroglycerin to be absorbed percutaneously at a controlled rate for a long period of time. Also, even a compact preparation can supply a sufficient amount of nitroglycerin. Moreover, the preparation can be manufactured at low cost without any complicated process.

REFERENCES:
patent: 4685911 (1987-08-01), Kono et al.
patent: 4751087 (1988-06-01), Wick
patent: 4971799 (1990-11-01), Nakagawa et al.

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