Percutaneous absorption preparation

Details Percutaneous absorption preparation Percutaneous absorption preparation

1995-04-28

1997-04-08

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424448, 424449, 514946, A61F 1300

Patent

active

056185553

ABSTRACT:
A percutaneous absorption preparation which is excellent in the skin penetration of a non-narcotic analgesic buprenorphine and can sustain a high blood level in a stable state over a long period of time is provided. The percutaneous absorption preparation for administrating buprenorphine hydrochloride and/or buprenorphine, which comprises a support having on one surface thereof a plaster layer containing a pressure-sensitive adhesive, buprenorphine hydrochloride and/or buprenorphine, and a penetration enhancer, wherein the penetration enhancer comprises a combination of a monoglyceride of a fatty acid having 6 to 8 carbon atoms and isopropyl myristate, and the plaster layer contains at least 10% by weight of a monoglyceride off fatty acid having 6 to 8 carbon atoms and at least 5% by weight off isopropyl myristate, with the proviso that the content of the whole penetration enhancer ranges from 25 to 50% by weight. The combined use of the fatty acid monoglyceride and isopropyl myristate as a penetration enhancer synergistically elevates skin penetration of buprenorphine hydrochloride and/or buprenorphine.

REFERENCES:
patent: 4626539 (1986-12-01), Aungst et al.
patent: 4806341 (1989-02-01), Chien
patent: 4844903 (1989-07-01), Seth
patent: 5026556 (1991-06-01), Drust
patent: 5069909 (1991-12-01), Sharma
patent: 5149538 (1992-09-01), Granger
patent: 5238933 (1993-08-01), Catz
patent: 5240711 (1993-08-01), Hille et al.

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