Peptides that stimulate cell survival and axon regeneration

Details Peptides that stimulate cell survival and axon regeneration Peptides that stimulate cell survival and axon regeneration

2007-12-04

2007-12-04

Kemmerer, Elizabeth C. (Department: 1646)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

C435S375000, C435S383000, C435S384000, C435S387000, C530S300000, C530S327000, C530S330000

Reexamination Certificate

active

10311509

ABSTRACT:
Peptides which consist of or comprise the tetrameric peptide structural unit: Xaa-Xaa-Xaa-Xaa in which Xaa at position1represents Glu or Asp, Xaa at position2represents any amino acid, Xaa at position3represents any amino acid and Xaa at position4represents Glu or Asp, each of the meanings of Xaa being independent, and peptides which consist of or comprise the sequence PYSSTA, particularly when in multimeric form, mimic the beneficial trophic and neuritogenic effects of FGF but lack the undesirable mitogenic effects. They are useful for the treatment of conditions for which FGF has been proposed, including treatment of neurodegenerative diseases, ischaemia, wound healing and stimulation of angiogenesis in cardiac muscle.

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