Peptides for the diagnosis of schizophrenia

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Reexamination Certificate

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Details

C435S007100, C436S503000, C424S185100

Reexamination Certificate

active

07354991

ABSTRACT:
Short peptides are provided, which bind to a body fluid sample obtained from a schizophrenic patient at a substantively higher level than to a body fluid sample obtained from a non-schizophrenic individual. The peptides are no more than 10 amino acids long and comprise a continuous sequence of at least 5 amino acids which consists of at least one positively charged amino acid at one of its ends. The provided peptides, which are the putative binding sites of autoantibodies found in high levels in schizophrenic individuals, are thus useful in diagnosis of schizophrenia.

REFERENCES:
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patent: WO 95/12685 (1995-05-01), None
patent: WO 95/23970 (1995-09-01), None
patent: WO 99/30163 (1999-06-01), None
patent: WO 99/51725 (1999-10-01), None
patent: WO 00/06723 (2000-02-01), None
UniProt Q9SVH3, internet printout from Oct. 31, 2006.
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Deckmann, M. et al. “A conformational epitope which detects autoantibodies from schizophrenic patients”,Clinica Chimica Acta, Elsevier Science B.V., vol. 322 pp. 91-98, 2002.
Shinitzky, M. et al. “Platelet Autoantibodies in Dementia and Schizophrenia”, Ann. NY Acad. Sci., vol. 621 pp. 205-217, 1991.
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Deckmann, M. et al. “Humoral and cellular response against autologous platelets in schizophrenia. Clinical and pathophysiological implications”,The Italian Journal of Psychiatry and Behavioral Sciences, Idelson Scientific Publications, vol. 6(2) pp. 29-34, (1996).
Carpenter, W. et al. “Schizophrenia”,The New England Journal of Medicine, vol. 330(10) pp. 681-690, (1994).

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