Peptides for inhibiting pepsin release

Details Peptides for inhibiting pepsin release Peptides for inhibiting pepsin release

1995-03-15

1997-09-16

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 14, 514 15, 514 16, 514 17, 530326, 530327, 530328, 530329, 530330, A61K 3800

Patent

active

056681097

ABSTRACT:
Peptides derived from the C terminal sequence of sorbin, but containing at least one D-amino acid residue, inhibit pepsin release and are therefore likely to be useful in the treatment of ulcers or oesophagitis. Their salts and substitution derivatives are also claimed as a pharmaceutical compositions containing them. A method for the treatment of a patient suffering from gastric ulcers or oesophagitis comprising the administration of said peptides, is also claimed.

REFERENCES:
Gastroenterology (1992), 103(5), 1568-73 Charpin, Ghislaine et al. Effect of sorbin on duodenal absorpiton of water and electrolytes in the rat.
Nicol et al., "Pharmacokinetics and Organ Distribution of the Sorbin C-Terminal Peptides." Peptides, 15(6), 1994, 1013-1019.

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