Peptides bearing N-terminal amidino moieties and their use as in

Details Peptides bearing N-terminal amidino moieties and their use as in Peptides bearing N-terminal amidino moieties and their use as in

1993-09-20

1995-07-04

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530331, 514 19, 514315, 546184, 548530, A61K 3806

Patent

active

054300240

ABSTRACT:
Acetic acid derivatives of formula

REFERENCES:
patent: 4055636 (1977-10-01), Okamoto et al.
patent: 4578079 (1986-03-01), Ruoslahti et al.
patent: 4683291 (1990-07-01), Zimmerman et al.
patent: 5039805 (1991-08-01), Alig et al.
patent: 5061693 (1991-10-01), Nutt et al.
patent: 5100875 (1992-03-01), Marguerie de Rotrou
patent: 5273982 (1993-12-01), Alig
Turner, et al., Biochemistry, 25:4929-4935 (1986) "p-Amidino Esters as Irreversible Inhibitors of Fac. IXa and Xa & Thrombin".
Steiner, et al., J. Biol. Chem., 264(22):13102-13108 (1989) "Ca.sup.2 -dependent Binding of a Synthetic Arg--Gly--Asp (RGD) Peptide . . . ".
Pierschbacker, et al., J. Biol. Chem., 292(36):17294-17298 (1987) "Influence of Stereochem. of the Sequence Arg--Gly--Asp.Xaa . . . ".
Saiki, et al., Jpn. J. Cancer Res., 81:660-667 (1990) "Anti-metastatic and Anti-invasive effects of polymeric Arg--Gly--Asp (RGD) Peptide, Poly(RGD), and its Analogues".
Saiki, et al., Br. J. Cancer, 60:722-723 (1989) "Antimetastatic efffects of synthetic polypeptides containing repeated . . . ".
Knudsen, et al., Exper. Cell Res., 179:42-49 (1988) "Trigramin, an RGD-Containing Peptide from Snake Venom . . . ".
Cook, et al., Tips Review, 11:444-451 (1990) "Fibrinogen as a major risk factor in cardiovascular disease".
Derwent 88-206834/30 (corresponding to EP 275 748--copy attached).

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