Peptide Y-2

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C514S002600, C514S021800, C424S439000, C426S657000

Reexamination Certificate

active

07112571

ABSTRACT:
Peptide which is obtained by treating fish meat such as sardine with an alkaline protease is adsorbed with a peptide-adsorbing resin (such as ODS resin) and eluted with 10 aqueous ethanol to obtain a peptide (Y-2 fraction). The resulting novel peptide has an excellent hypotensive action and can be used as a nutrient and a specific health food and, in addition, it can be advantageously used as a hypotensive agent.

REFERENCES:
patent: 4853231 (1989-08-01), Osajima et al.
patent: 4981699 (1991-01-01), Inada et al.
patent: 5-271297 (1993-10-01), None
English Abstract of JP-6-249000 (Sep. 6, 1994).
English Abstract opf JP-6-239897 (Aug. 30, 1994).
English Abstract of JP-11-228599 (Aug. 24, 1999).
English Abstract of JP-11-80018 (Mar. 23, 1999).
H. Cheung et al.,J. Biol. Chem., vol. 255, No. 2, pp. 401-407 (Jan. 25, 1980).
Abstract of The Congress of Japan Society for Bioscience, Biotechnology and Agrochemistry, vol. 67, No. 3, 1993 (English Translation).
T. Kawasaki et al., “Hypotensive Effect of a Short Chain Peptide, Valyl-tyrosine, Derived from Sardine Protein on Subjects with Slight Hypertension”,The 21stAnnual Scientific Meeting of the Japanese Society of Hypertension, Sep. 24-26, 1998.
T. Kawasaki et al., Journal of Hypertension, Abstracts presented at the 17thScientific Meeting of the International Society of Hypertension, Jun. 7-11, 1998, Amsterdam, Netherlands, Abstract Nos. 3XP2, 11Z.3, P17.43.
T. Matsui et al.,Biosci. Biotech. Biochem., 57 (6) 922-925, 1993.

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