Peptide nucleic acids

Details Peptide nucleic acids Peptide nucleic acids

1993-04-26

1996-07-23

Walsh, Stephen G.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

536 187, 536 243, 544242, 544264, C07K 700, C07H 504, C07H 2104, C07D23900

Patent

active

055390820

ABSTRACT:
A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

REFERENCES:
patent: 5134066 (1992-07-01), Rogers et al.
patent: 5142047 (1992-08-01), Summerton et al.
Takemoto et al "Sythetic Nucleic Acid Analogs . . . " Adv. Poly. Sci. 41:1-51 (1981).
Buttrey et al "Synthetic Analogues of Polynucleotides . . . " Tetrahedron 31:73-75. (Jan. 1975).
Doel et al, "The Synthesis of Peptides Containing Purine and Pyrimidine Derivatives of DL-Alanine", Tetrahedron 30:2755-2759 (1974).
Lu et al, "Synthesis of Polyesters Containing Nucleic Acid Base Derivatives as Pending Side Chains", J. Poly. Sci.: Part A: Poly Chem. 24:525-536 (1986).
Meier et al "Peptide Nucleic Acids (PNAs) . . . " Angew. Chem. Int. Ed. Eng. 31(8):1008-1010 (Jul. 1992).
Gewirtz, "Therapeutic Application of Antisense DNA . . . ", pp. 178-187 in Antisense Strategies, published 1992 by NYAS.
Hyrup et al, "Modification of the Binding Affinity of Peptide Nucleic Acids (PNA) . . . " J. Chem. Soc. Chem. Commun. pp. 518-519 (Mar. 1993).
Nielsen et al "Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide", Science 254:1497-1500 (Dec. 1991).
Egholm et al "Peptide Nucleic Acids (PNA) . . . " J. Am. Chem. Soc. 114:1895-1897 (Feb. 1992).
Egholm et al, "Peptide Nucleic Acids (PNA) . . . ", pp. 325-328, in Innovation and Perspectives in Solid Phase Synthesis, Collected Papers (1992).
Hanvey et al, "Antisense and Antigene Properties of Peptide Nucleic Acids" Science 258:1481-1485 (Nov. 1992).
McCurdy et al., "Deoxyoligonucleotides with Inverted Polarity: Synthesis and Use in Triple-Helix Formation," Nucleosides and Nucleotides, 10:287-290, 1991.
Froehler et al., "Oligodeoxynucleotides Containing C-5 Propyne Analogs of 2'-Deoxyuridine and 2'-Deoxycytidine," Tetrahedron Letters, 33:5307-5310, 1992.
Sagi et al., "Base-Modified Oligodeoxynucleotides. I. Effect of 5-Alkyl, 5-(1-Alkenyl) and 5-(1-Alkynyl) Substitution of the Pyrimidines on Duplex Stability and Hydrophobicity," Tetrahedron Letters, 34:2191-2194, 1993.
Spalholtz et al., "Bovive papillomavirus Transcriptional Regulation: Localization of the E2-Responsive Elements of the Long Control Region," J. Virol., 61:2128-2137, 1987.
Dubochet et al., "A New Preparation Method for Dark-Field Electron Microscopy of Biomacromolecules," J. Ultrastruct. Res., 35:147-167, 1971.
Vickers, et al., "Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element," Nucleic Acids Research, 19:3359-3368, 1991.
Stenberg et al., "Promoter-Specific trans Activation and Repression by Human Cytomegalovirus Immediate-Early Proteins Invovles Common and Unique Protein Domains," J. Virol., 64:1556-1565, 1990.
Hahn et al., "Molecular cloning and characterization of the HTLV-III virus associated with AIDS," Nature, 312:166-169, 1984.
Depto et al., "Regulated Expression of the Human Cytomegalovirus pp65 Gene: Octamer Sequence in the Promoter Is Required for Activation by Viral Gene Products," J. Virol., 1989, 63:1232-1238, 1989.
Tibanyenda et al., "The effect of single base-pair mismatches on the duplex stability of d(T-A-T-T-A-A-T-A-T-C-A-A-G-T-T-G).d(C-A-A-C-T-T-G-A-T-A-T-T-A-A-T-A)," Eur. J. Biochem., 139:19-27, 1984.
Vasseur et al., "Oligonucleosides: Synthesis of a Novel Methylhydroxylamine-Linked Nucleoside Dimer and Its Incorporation into Antisense Sequences," J. Am. Chem. Soc., 114:4006-4007, 1992.
Lal et al., "Diphenylphosphoryl Azide A Novel Reagent for the Stereospecific Synthesis of Azides from Alcohols," Tetrahedron Letters, 23:1977-1980, 1977.
Almarsson, O. et al., "Molecular Mechanics Calculations of the Structures of Polyamide Nucleic Acid DNA Duplexes and Triple Helical Hybrids", PNAS USA 1993, 90, 7518-7522.

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