Peptide inhibitors of mitogenesis and motogenesis

Details Peptide inhibitors of mitogenesis and motogenesis Peptide inhibitors of mitogenesis and motogenesis

1994-06-27

1997-01-14

Nucker, Christine M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530300, 530324, 530327, 530328, 530334, A61K 3810, C07K 700

Patent

active

055941052

ABSTRACT:
The invention in the field of cell biology relates to novel peptides able to interact with intracellular signal transducers, thus interfering with signal transduction pathways leading to cell proliferation and motility. The peptides of the invention may be chemically synthesized from single amino acids and/or preformed peptides of two or more amino acid residues.
The peptides of the invention find an useful application in the treatment of a neoplastic disease.

REFERENCES:
Molecular and Cellular Biology, vol. 13, No. 3, Mar. 1993, S. Felder, et al., "SH2 Domains Exhibit High-Affinity Binding to Tyrosine-Phosphorylated Peptides Yet Also Exhibit Rapid Dissociation And Exchange", pp. 1449-1455.
Nature, vol. 369, No. 6480, Jun. 9, 1994, Luc. E. M. Marengere, et al., "SH2 Domains Specificity And Activity Modified By A Single Residue", pp. 502-505.
Cell, vol. 77, No. 2, Apr. 1994, pp. 261-271, C. Ponzetto, et al., "A Multifunctional Docking Site Mediates Signaling and Transformation By The Hepatocyte Growth Factor/Scatter Factor Receptor Family".
Molecular and Cellular Biology, vol. 13, No. 8, Aug. 1993, pp. 4600-4608, C. Ponzetto, et al., "A Novel Recognition Motif For Phosphatidylinositol 3-Kinase Binding Mediates Its Association With The Hepatocyte Growth Factor/Scatter Factor Receptor".
Songyang et al, "SH2 Domains Recognize Specific Phosphopeptide Sequences", Cell, vol. 72, pp. 767-778 (Mar. 12, 1993).
Fantl et al, "Distinct Phosphotyrosines On A Growth Factor Receptor Bind To Specific Molecules That Mediate Different Signaling Pathways", Cell, vol. 69, Pates 413-423 (May 1, 1992).
Sawyers et al, "Chronic Myelomonocytic Leukemia: Tel-A-Kinase What Ets All About", Cell, vol. 77, pp. 171-173 (Apr. 22, 1994).

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