Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.
Patent
1998-03-16
2000-09-26
Borin, Michael
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Tripeptides, e.g., tripeptide thyroliberin , etc.
514 18, 530830, C07K 508, C07K 510, A61K 3806, A61K 3807
Patent
active
061244317
ABSTRACT:
A peptide derivative represented by the following formula or a salt thereof ##STR1## wherein A represents a hydrogen atom, and B represents a phenyl group substituted with a hydroxyl group;
said derivative has an antitumor activity stronger than that of dolastatin 10, and is useful as an anticancer or antitumor agent.
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Pettit et al., The Isolation and Structure of a Remarkable Marine Animal Antineoplastic Constituent: Dolastatin 10.sup.1a, J. Am. Chem. Soc., 1987, 109, 6883-6885.
Gondo Masaaki
Ito Takeshi
Kobayashi Motohiro
Miyazaki Koichi
Sakakibara Kyoichi
Borin Michael
Teikoku Hormone Mfg. Co. Ltd.
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