Peptide conjugates for transfecting cells

Details Peptide conjugates for transfecting cells Peptide conjugates for transfecting cells

1997-01-14

2000-02-29

Achutamurthy, Ponnathapu

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 165, 4284022, 554 81, 530324, A61K 5100, A61K 3800, B32B 516, C07F 902

Patent

active

060306025

ABSTRACT:
The invention relates to conjugates of lipids and basic, membrane disturbing peptides, particularly compounds of the formula

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Saberwal, et al. Cell-lytic and antibacterial peptides that act by perturbing the barrier function of membranes: facets of their conformational features, structure-function correlations and membrane-perturbing abilities, Biochimica et Biophysics Acta 1197, pp. 109-131 (1994).
Felgner, et al., Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure, Proc. Natl. Acad. Sci. USA, vol. 84, pp. 7413-7417 (1987).
Ferderigos, et al., Synthesis of [A-2-.alpha..gamma.-Diaminobutyric Acid, A-19-Glutamic Acid] Sheep Insulin, J. Chem. Soc. Perkin Trans, vol. 11, pp. 1299-1305 (1977).

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