Penam sulfones as .beta.-lactamase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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Details

540310, C07D49908, C07D49900, A61K 3143

Patent

active

056864418

ABSTRACT:
Novel 4,4-dioxides which are of value for use in combination with .beta.-lactam antibiotics to increase the effectiveness of the antibiotics.

REFERENCES:
patent: 4234579 (1980-11-01), Barth
patent: 4562073 (1985-12-01), Micetich et al.
Gottstein et al., J. Med. Chem., "Synthesis and .beta.-Lactamase Inhibitory Properties of 2.beta.-(Chloromethyl)-2.alpha.-methylpenam-3.alpha.-carboxylic Acid 1,1-Dioxide", vol. 24, No. 12, pp. 1531-1534 (1981).
Gottstein et al., J. Med. Chem., "Synthesis and .beta.-Lactamase Inhibitory Acid 1,1-Dioxides", vol. 28, No. 4, pp. 518-522 (1985).
Tanaka et al., J. Antibiotics, "Synthesis and .beta.-Lactamase Inhibitory Properties of 2.beta.-(Thio-Substituted Methyl)-Penam 1, 1-Dioxides", vol. XLI, No. 4, pp. 579-582 (1988).
Poster No. 147, ICAAC, Oct. 4-7, 1994, Orlando, Florida.
Poster No. 149, ICAAC, Oct. 4-7, 1994, Orlando, Florida.
Poster No. 151, ICAAC, Oct. 4-7, 1994, Orlando, Florida.
Poster No. 153, ICAAC, Oct. 4-7, 1994, Orlando, Florida.
Poster No. 155, ICAAC, Oct. 4-7, 1994, Orlando, Florida.
Lunn and Hipskind; Tetrahedron Letters; The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry; Oct. 13, 1992; vol. 33, No. 42 pp. 6291-6294.

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