Penam derivatives and salts thereof, process for producing the s

Details Penam derivatives and salts thereof, process for producing the s Penam derivatives and salts thereof, process for producing the s

1992-10-07

1994-04-05

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540304, A61K 31425, C07D49900

Patent

active

053004973

ABSTRACT:
A penam derivative represented by the following general formula or a salt thereof: ##STR1## wherein R.sup.1 represents a hydrogen atom, an amino-protecting group or an acyl group; R.sup.2 represents a hydrogen atom or a lower alkyl group; R.sup.3 represents a hydrogen atom, a lower alkoxy group, a lower alkylthio group or a formamido group; R.sup.4 represents an protected or unprotected carboxyl group or a carboxylato group; R represents a group of the formula, --NHR.sup.5 or --NR.sup.5 R.sup.6 (in which R.sup.5 and R.sup.6, which may be the same or different, represent protected or unprotected hydroxyl groups, cyano groups, sulfo groups, or unsubstituted or substituted lower alkyl, aryl, acyl, carbamoyl, sulfamoyl, lower alkylsulfonyl or heterocyclic groups) or a group of the formula, --N.dbd.CR.sup.7 R.sup.8 (in which R.sup.7 and R.sup.8, which may be the same or different, represent hydrogen atoms or protected or unprotected carboxyl groups, cyano groups or unsubstituted or substituted lower alkyl, lower alkenyl, lower alkynyl, aryl, amino, acyl, acyloxy, carbamoyl, carbamoyloxy, sulfamoyl, lower alkylthio, ureido or heterocyclic groups, or R.sup.7 and R.sup.8 may form a cycloalkene or a heterocyclic ring with the carbon atom to which R.sup.7 and R.sup.8 are attached); and n represents 1 or 2. The above penam derivative or its salt is very effective as antibacterial agents.

REFERENCES:
patent: 4717767 (1988-01-01), Sadaki et al.
patent: 4948796 (1990-08-01), Hiraiwa et al.
patent: 5185330 (1993-02-01), Ochiai et al.
Patent Abstracts of Japan, vol. 12, No. 462 (C-549)(3309), Dec. 5, 1988, & JP-A-63 183 588, Jul. 28, 1988, Y. Ochiai, et al., "Novel Penam Derivative and Salt Thereof".

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