Data processing: structural design – modeling – simulation – and em – Simulating nonelectrical device or system – Biological or biochemical
Reexamination Certificate
2007-03-13
2007-03-13
Jones, Hugh (Department: 2128)
Data processing: structural design, modeling, simulation, and em
Simulating nonelectrical device or system
Biological or biochemical
C703S002000, C703S006000, C434S262000, C434S268000, C434S270000
Reexamination Certificate
active
09400365
ABSTRACT:
A method and apparatus are provided for modeling circulation in a living subject. The method includes the steps of developing a model for living subjects in general and correcting the model to substantially conform to the overall cerebral physiology of the living subject. The method further includes the step of calculating a cerebral flow of the living subject based upon the corrected model and a selected cerebral blood flow perturbation.
REFERENCES:
patent: 3802096 (1974-04-01), Matern
patent: 5680590 (1997-10-01), Parti
patent: 6117087 (2000-09-01), Kamm et al.
Karplus, W. et al. “Simulation and Visualization of the Fluid Flow Field in Aneurysms: A Virtual Environments Methodology,” Proc. of 7th Int'l Symp. of Micro Machine and Human Science, Oct. 1996, pp. 35-41.
Foutrakis, G. “Finite Element Modeling of Intracranial Arterial Blood Flow and Saccular Aneurysm Formation,” 1994 [retrieved on Jun. 5, 2000]. Retrieved from the Internet: <URL: neuronet.pitt.edu/˜georgef/fem.html>.
Foutrakis, G. “Efficient Segmentation and 3-D Resonstruction of Complex Vascular Structures from Magnetic Resonance Angiography Imaging Data,” 1994 [retrieved on Jun. 5, 2000]. Retrieved from the Internet: <URL: neuronet.pitt.edu/˜georgef/mra—seg.html>.
Foutrakis, G. “Construction of 3-D Intracranial Arterial Meshes from Magnetic Resonance Angiography,” 1994 [retrieved on Jun. 5, 2000]. Retrieved from the Internet: <URL: neuronet.pitt.edu/˜georgef/mra2mesh.html>.
Silipo, R. et al. “Dynamics Modelling in Brain Circulation,” Proc. of 1997 IEEE Workshop in Neural Networks for Signal Processing, Sep. 1997, pp. 162-171.
Ramalinga, S. et al. “Hemodynamics of Intravascular Lateral Aneurysms: Flow Siimulation Studies,” Proc. of 1997 16th Southern Biomedical Engineering Conf., Apr. 1997, pp. 224-227.
Wolk, S. et al. “Computer Simulation of Cerebrovascular Circulation and Assessment of Intracranial Hemodynamics during Induction of Anesthesia,” Proc. of 1995 IEEE 21st Annual Northeast Bioengineering Conf., May 1995, pp. 95-96.
Ortega, V. “Predicting Cerebral Aneurysms with CFD,” Technical Engineering, vol. 119, No. 1, Jan. 1997, pp. 76-77.
Hademenos, G. “The Biophysics of Stroke,” American Scientist, vol. 85, No. 3, May-Jun. 1997, pp. 226-235.
AnalyzeAVW—product overview, 1997 [retrieved on Jun. 5, 2000]. Retrieved from the Internet: <URL: www.mayo.edu/bir/analyzeavw/analyzeavw—new.html>.
TCD Simulator—product overview, 1999 [retrieved on Jun. 5, 2000]. Retrieved from the Internet: <URL: www.hemodynamic.com>.
J.R. Womersley, “Oscillatory Flow in Arteries: The Constrained Elastic Tube as a Model of Arterial Flow and Pulse Transmission”,Phys. in Med.&Biol.,vol. 2, pp. 178-187 (1958).
Ling, et al., “A Nonlinear Analysis of Pulsatile Flow in Arteries”,J. Fluid Mech.,vol. 55, part 3, pp. 493-511 and illustration facing p. 512 (1972).
Kufahl, et al., “A Circle of Willis Simulation Using Distensible Vessels and Pulsatile Flow”,Journal of Biomechanical Engineering,vol. 107, pp. 112-122 (May 1985).
Clark, et al., “Natural and Surgically Imposed Anastomoses of the Circle of Willis”,Neurological Research,vol. 11, pp. 217-230 (Dec. 1989).
Chao & Hwang, “Functional Dynamics of the Circle of Willis”, 1972, T.I.T.Journal of Life Sciences,vol. 2, pp. 81-88.
Charbel, et al., abstract: “Predictive Value of a Computerized Model of the Cerebral Circulation”, Oct. 1994, 44th Annual Meeting, Congress of Neurological Surgeons.
Charbel, et al., abstract: “Validation and Clinical Potential of a Computerized Model of the Cerebral Circulation”, Jan. 1996, First Annual Meeting of the Joint Section on Cerebrovascular Surgery of the American Association of Neurological Surgeons and the Congress of Neurological Surgeons.
Charbel, et al., abstract: “Phase Contrast MR Flow Measurement System Using Volumetric Flow Constrainted Image Interpolation and Color Coded Image Visualization”, Sep. 1997, 47th Annual Meeting, Congress of Neurological Surgeons.
Clark and Kufahl, “Simulation of the Cerebral Macrocirculation”, from MIT Press, pp. 380-390 inCardiovascular System Dynamics(Baan, et al., Editors).
Clark, et al., “Engineering Analysis of the Hemodynamics of the Circle of Willis”, Aug. 1965,Archives of Neurology,vol. 13, pp. 173-182.
Clark, et al., “Simulation Studies of Factors Influencing the Cerebral Circulation”, 1967,Acta Neurol. Scandinav.,vol. 43, pp. 189-204.
Duros, et al., “On the Rupture of an Aneurysm”, May 1991, University of Illinois (Urbana) Dept. of Theoretical and Applied Mechanics.
Fukushima, et al., “Vortex Generation in Pulsatile Flow Through Arterial Bifurcation Models Including the Human Carotid Artery”, Aug. 1988,Transactions of the ASME,vol. 110, pp. 166-171.
Helal, “Derivation of Closed-Form Expression for the Cerebral Circulation Models”, 1994,Comput. Biol. Med.,vol. 24, pp. 103-117.
Hillen, et al., “A Mathematical Model of the Flow in the Posterior Communicating Arteries”, 1982,J. Biomechanics,vol. 15, No. 6, pp. 441-448.
Hillen, et al., “A Mathematical Model of the Flow in the Circle of Willis”, 1986,J. Biomechanics,vol. 19, No. 3, pp. 187-194.
Hillen, et al., “Analysis of Flow and Vascular Resistance in a Model of the Circle of Willis”, 1988,J. Biomechanics,vol. 21, No. 10, pp. 807-814.
Himwich, et al., “The Circle of Willis as Simulated by an Engineering Model”, Aug. 1965,Arch. Neurol.,vol. 13, pp. 164-172.
Himwich and Clark, “Simulation of Flow and Pressure Distributions in the Circle of Willis”, 1974,Pathology of Cerebral Microcirculation, Berlin Symposium.
Imaeda and Goodman, “Analysis of Non-Linear Pulsatile Blood Flow in Arteries”, 1980,J. Biomechanics, vol. 13, pp. 1007-1022.
Kufahl, Ph.D. thesis: “Numerical Solution of Unsteady Viscous Flow in Looping Arterial Networks”, 1979, University of Illinois (Urbana) Graduate College, 392 pages plus abstract and table of contents.
Kufahl and Clark, “A Circle of Willis Simulation Using Distensible Vessels and Pulsatile Flow”, May 1985,Journal of Biomechanical Engineering,vol. 107, pp. 112-122 and errata, p. 320 (Nov. 1985).
Leipsch and Moravec, “Pulsatile Flow of Non-Newtonian Fluid in Distensible Models of Human Arteries”, 1984,Biorheology,vol. 21, pp. 571-586.
Ling and Atabek, “A Nonlinear Analysis of Pulsatile Flow in Arteries”, 1972,J. Fluid Mech.,vol. 55, part 3, pp. 493-511.
Perktold, et al., “Pulsatile Non-Newtonian Blood Flow Simulation Through a Bifurcation with an Aneurysm”, 1989,Biorheology,vol. 26, pp. 1011-1030.
Perktold and Peter, “Numerical 3D-Simulation of Pulsatile Wall Shear Stress n an Arterial T-Bifurcation Model”, Sep. 1990,J. Biomed. Eng.,vol. 12, pp. 2-12.
Perktold, et al., “Pulsatile non-Newtonian Blood Flow in Three-Dimensional Carotid Bifurcation Models: A Numerical Study of Flow Phenomena Under Different Bifurcation Angles”, Nov. 1991,J. Biomed. Eng.,vol. 13, pp. 507-515.
Perktold, et al., “Three-Dimensional Numerical Analysis of Pulsatile Flow and Wall Shear Stress in the Carotid Bifurcation”, 1991,J. Biomechanics,vol. 24, No. 6, pp. 409-420.
Porenta, et al., “A Finite-Element Model of Blood Flow in Arteries Including Taper, Branches, and Obstructions”, May 1986,Journal of Biomechanical Engineering,vol. 108, pp. 161-167.
Raines, et al., “A Computer Simulation of Arterial Dynamics in the Human Leg”, 1974,J. Biomechanics,vol. 7, pp. 77-91.
Raines, et al., “A Computer Simulation of the Human Arterial System”, 1975, Summer Computer Conference Proceedings.
Roller and Clark, “Precursor Cerebr
Alperin Noam
Charbel Fady T.
Clark Marlyn E.
Loth Francis
Sadler Lewis
Jones Hugh
University of Illinois Board of Trustees
LandOfFree
Patient specific circulation model does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Patient specific circulation model, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Patient specific circulation model will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3787465