Parenteral formulations of 1-diphenylmethyl-4-((2-(4-methylpheny

Details Parenteral formulations of 1-diphenylmethyl-4-((2-(4-methylpheny Parenteral formulations of 1-diphenylmethyl-4-((2-(4-methylpheny

1990-09-20

1991-11-05

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ortho-hydroxybenzoic acid or derivative doai

514255, A61K 3162, A61K 31495

Patent

active

050632205

ABSTRACT:
A pharmaceutical formulation suitable for parenteral (preferably intravenous) administration includes an effective amount of 1-diphenylmethyl-4-[(2-(4-methylphenyl)-5-methyl-1H-imidazol-4-yl)methyl]p iperazine and a suitable amount of an acid to generate a pharmaceutically acceptable salt having a pH above about 3.0 and a solubility above about 4.0 mg/ml. The intravenous formulation optionally includes a suitable tonicifier in a quantity sufficient to achieve isotonicity with body fluids. The salt is formed in situ during the formulation process. The salt of tartaric acid is preferred; suitable salts for lower concentration dosages are the citric acid and methane sulphonic acid salts.

REFERENCES:
patent: 3362956 (1968-01-01), Archer
patent: 3491098 (1970-01-01), Archer
patent: 3631043 (1971-12-01), Regnier et al.
patent: 3649631 (1972-03-01), Koppe et al.
patent: 3927011 (1975-12-01), Nakanishi et al.
patent: 4022783 (1977-05-01), Shroff et al.
patent: 4243806 (1981-01-01), Raeymaekers et al.
patent: 4404382 (1983-07-01), Gall

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