Parasitic helminth asparaginase proteins, nucleic acid molecules

Details Parasitic helminth asparaginase proteins, nucleic acid molecules Parasitic helminth asparaginase proteins, nucleic acid molecules

1997-09-15

1998-12-29

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435228, 435229, 4352523, 43525233, 4353201, 536 232, 536 234, 536 231, C12N 982, C12N 120, C07H 2104

Patent

active

058540512

ABSTRACT:
The present invention relates to: parasitic helminth asparaginase proteins; parasitic helminth asparaginase nucleic acid molecules, including those that encode such asparaginase proteins; antibodies raised against such asparaginase proteins; and compounds that inhibit parasitic helminth asparaginase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.

REFERENCES:
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Wilson et al., 1994, "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans," Nature 368, pp. 32-38.
Zhang et al., 1995, "Guinea pig serum L-asparaginase: purification, and immunological relationship to liver L-asparaginase and serum L-asparaginases in other mammals," Comp. Biochem. Pjysiol. 112B:4, pp. 607-612.

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