Pancreatic lipase inhibitor compounds, their synthesis and use

Details Pancreatic lipase inhibitor compounds, their synthesis and use Pancreatic lipase inhibitor compounds, their synthesis and use

2006-06-20

2006-06-20

Berch, Mark L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S091000, C544S048000, C206S570000, C549S068000

Reexamination Certificate

active

07064122

ABSTRACT:
The subject invention features compounds having the structure:wherein X is O, S, CH2or NR5; Y is O or S; R1is H, substituted or unsubstituted C1-C15alkyl, C1-C8alkylaryl, —C(O)OR4, —C(O)NR4R5, —CR6R6′OR4, —CR6R6′OC(O)R4, —CR6R6′OC(O)NHR7, —C(O)NR10R11, —C(O)NR8R9NR8R9, —N(R5)C(O)NHR5, or CH2R4; R2is a substituted or unsubstituted, straight chain C1—C30alkyl or branched C3-C30alkyl, aryl, alkylaryl, arylalkyl, heteroarylalkyl or cycloalkyl; R3is H or substituted or unsubstituted C1-C6alkyl or C3-C10cycloalkyl; R4is H or a substituted or unsubstituted, straight chain or branched, C6-C30alkyl, aryl, —CH2-aryl, aryl —C1-C15alkyl, heteroaryl-C1-C15alkyl or C3-C10cycloalkyl; R5is H or a substituted or unsubstituted, straight chain or branched, C6-C30alkyl, aryl C1-C30alkyl, heteroarylalkyl or cycloalkyl; R6and R6′are each independently H, substituted or unsubstituted C1-C6alkyl, dialkyl or C3-C10cycloalkyl or together form a 3-7 membered ring system; R7is H or substituted or unsubstituted C1-C12alkyl or C3-C10cycloalkyl; R8and R9are each independently H, substituted or unsubstituted C1-C6alkyl, C1-C6alkoxy, C1-C6alkylaryl, or NR8R9together form a substituted piperazine or piperidine ring or a dihydro-1H-isoquinoline ring system, or a specific enantiomer thereof, or a specific tautomer, or a pharmaceutically acceptable salt thereof and a method for treating diabetes or obesity by administering a therapeutically effective amount of the compounds of the invention.

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