Palladium mediated reaction of organic disulfides with mercurate

Details Palladium mediated reaction of organic disulfides with mercurate Palladium mediated reaction of organic disulfides with mercurate

1988-04-11

1991-01-08

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536120, 536 41, C07H 1900

Patent

active

049837273

ABSTRACT:
A method of preparing C-5 substituted nucleotides by reacting a C-5 posit mercurated nucleoside with an alkyl or aryl disulfide in the presence of palladium(II) ion. The resulting new method for attaching linker arms to nucleic acids (DNA,RNA) provides a wide ranging reaction far more useful than those heretofore developed, and allows preparation of modified components with linking reactive functionality that allows usefulness as probes, therapeutics, and for DNA sequencing.

REFERENCES:
patent: 4247544 (1981-01-01), Bergstrom et al.
patent: 4267171 (1981-05-01), Bergstrom et al.
patent: 4711955 (1987-12-01), Ward et al.

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