Process for preparing nitrosourea derivatives

Details Process for preparing nitrosourea derivatives Process for preparing nitrosourea derivatives

1989-11-24

1991-01-08

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514908, 536 53, 536 55, A61K 3104, C07C125065, C07C11100, C07H 506

Patent

active

049837265

ABSTRACT:
The invention relates to nitrosourea derivatives, a process for their preparation and pharmaceutical compositions containing them.
The nitrosourea derivatives of the invention correspond to the following formula (I): ##STR1## in which: R can represent a hydrogen atom or an alkyl group from 1 to 30 carbon atoms, X represents a hydroxy group or an -NR.sub.1 R.sub.2 group, Y represents a hydrogen atom, a hydroxy group or an -NR'.sub.1 R'.sub.2 group, where R.sub.1 and/or R'.sub.1 each represent a hydrogen atom or a ##STR2## group, Hal being a halogen, and R.sub.2 and/or R'.sub.2 can each represent a hydrogen atom or an alkyl group comprising from 1 to 6 carbon atoms, R' and R" can represent hydrogen or OH, provided that at least X represents ##STR3## with R.sub.1 representing ##STR4## or Y represents ##STR5## with R'.sub.1 representing ##STR6## and provided that either R' represents hydrogen or R" represents hydrogen, and R' and R" cannot be simultaneously hydrogen atoms.
These compounds present an antitumor activity.

REFERENCES:
patent: 3940383 (1976-02-01), Fujiwara et al.
patent: 4241052 (1980-12-01), Tsujihara
patent: 4273766 (1981-06-01), Stanek
patent: 4472379 (1984-09-01), Suami et al.
patent: 4472573 (1984-09-01), Morikawa et al.
patent: 4593090 (1986-06-01), Kimura et al.

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